Strain Data Sheet
RBRC12185
Strain Information | |
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| Image | |
| BRC No. | RBRC12185 |
| Type | Targeted Mutation and Transgene |
| Species | Mus musculus |
| Strain name | B6.Cg-Tg(Aif1-tTA)75Kftnk Bdnf<tm1.1(tetO)Kftnk> |
| Former Common name | Iba1-tTA/BDNF tetO knockin double transgenic |
| H-2 Haplotype | |
| ES Cell line | G0G1 |
| Background strain | |
| Appearance | |
| Strain development | |
| Strain description | |
| Colony maintenance | |
| References | Brain-derived neurotrophic factor from microglia regulates neuronal development in the medial prefrontal cortex and its associated social behavior. Takashi Komori, Kazuya Okamura, Minobu Ikehara, Kazuhiko Yamamuro, Nozomi Endo, Kazuki Okumura, Takahira Yamauchi, Daisuke Ikawa, Noriko Ouji-Sageshima, Michihiro Toritsuka, Ryohei Takada, Yoshinori Kayashima, Rio Ishida, Yuki Mori, Kohei Kamikawa, Yuki Noriyama, Yuki Nishi, Toshihiro Ito, Yasuhiko Saito, Mayumi Nishi, Toshifumi Kishimoto, Kenji F Tanaka, Noboru Hiroi, Manabu Makinodan Mol. Psychiatry, 29(5):1338-1349 (2024). 38243072 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
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| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Bdnf MGI:88145 | brain derived neurotrophic factor | 2 | Bdnf<tm1.1(tetO)Kftnk> | targeted mutation 1, Kenji Tanaka | |||
| Frt | yeast FRT (flippase recombination target) site | 2 | Frt | ||||
| loxP | phage P1 loxP | 2 | loxP | ||||
| loxP | phage P1 loxP | 2 | loxP | ||||
| tetO | tetracycline operator (E. coli) | 2 | tetO | ||||
| tTA | tTA (E. coli tet repressor (TetR), herpes simplex virus (HSV) VP16 activation domain) | UN | tTA | mouse Aif1 promoter | |||
Phenotype | |
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| Phenotype annotation from literatures by Mammalian phenotype ontology | |
| Detailed phenotype data | |
Ordering Information | |
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| Donor DNA | mouse Aif1 promoter, tTA (E. coli tet repressor (TetR), herpes simplex virus (HSV) VP16 activation domain), Bovine Growth Hormone polyA additional signal, yeast FRT (flippase recombination target) site, E. coli Tetracycline operator site, Cytomegalovirus CMV minimal promoter, phage P1 loxP sites, mouse Bdnf genomic DNA |
| Research application | Tet system |
| Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
| Depositor | Kenji Tanaka (Keio University) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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| No Data |