Strain Data Sheet

RBRC12125

Strain Information

Image
BRC No.RBRC12125
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6-Il21<tm1.1Kubo>
Former Common nameIL-21 conditional knockout mice, Il21 f/f mice
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Protective neutralizing influenza antibody response in the absence of T follicular helper cells.
Kosuke Miyauchi, Akiko Sugimoto-Ishige, Yasuyo Harada, Yu Adachi, Yoshiko Usami, Tomohiro Kaji, Kentaro Inoue, Hideki Hasegawa, Takashi Watanabe, Atsushi Hijikata, Satoshi Fukuyama, Tadashi Maemura, Mariko Okada-Hatakeyama, Osamu Ohara, Yoshihiro Kawaoka, Yoshimasa Takahashi, Toshitada Takemori, Masato Kubo
Nat. Immunol., 17(12) 1447-1458 (2016). 27798619

Health Report

Examination Date / Room / Rack2025/11/04Room:3-6Rack:DSentinel mouse program
2025/08/18Room:3-6Rack:DSentinel mouse program
2025/06/09Room:3-6Rack:DSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site3Frt
Il21
MGI:1890474		interleukin 213Il21<tm1.1Kubo>
MGI:6149152		targeted mutation 1.1, Masato Kubo
  • IL21-related infantile inflammatory bowel disease(MedGEN)
    • loxP phage P1 loxP3loxP
    loxP phage P1 loxP3loxP

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, yeast FRT (flippase recombination target) site, mouse Il21 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat. Immunol., 17(12) 1447-1458 (2016).
    DepositorMasato Kubo (RIKEN IMS)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data