Strain Data Sheet

RBRC11844

Strain Information

Image
BRC No.RBRC11844
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tg(TRE-Scop/Phlpp1)1Shimk
Former Common nameTRE-Scop/Phlpp1 transgenic mouse
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus.
K Shimizu, M Okada, A Takano, K Nagai
FEBS Lett., 458(3):363-9 (1999). doi: 10.1016/s0014-5793(99)01190-4. 10570941

PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth.
Tianyan Gao, Frank Furnari, Alexandra C Newton
Mol. Cell., 18(1):13-24 (2005). doi: 10.1016/j.molcel.2005.03.008. 15808505

Proteolytic degradation of SCOP in the hippocampus contributes to activation of MAP kinase and memory.
Kimiko Shimizu, Trongha Phan, Isabelle M Mansuy, Daniel R Storm
Cell, 128(6):1219-29 (2007). doi: 10.1016/j.cell.2006.12.047. 17382888

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
HBB2Rabbit beta-globin polyA signalUNHBB2
Phlpp1PH domain and leucine rich repeat protein phosphatase 1 (rat)UNPhlpp1E. coli TRE promoter (tetracycline responsive promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNAE. coli TRE (Tetracycline response element), minimal CMV promoter, Rat Scop/Phlpp1 cDNA, Rabbit beta-globin poly A signal
Research applicationTet system
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell, 128(6):1219-29 (2007). doi: 10.1016/j.cell.2006.12.047.　　　　The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit organization for a not-for-profit research. The RECIPIENT agrees to notify the DEPOSITOR upon filing a patent application claiming modifications created by the RECIPIENT that contain or incorporate the BIOLOGICAL RESOURCE or method(s) of manufacture or use(s) of the BIOLOGICAL RESOURCE.
DepositorKimiko Shimizu (Tokyo Medical and Dental University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data