Strain Data Sheet

RBRC11814

Strain Information

Image
BRC No.RBRC11814
TypeCRISPR/Cas9 (Transgene)Cartagena
SpeciesMus musculus
Strain nameC57BL/6J-Fads1/Fads2<em2Tkato>
Former Common nameFads(delta/+), Fads(delta/delta)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice.
Hirona Yamamoto, Hyeon-Cheol Lee-Okada, Masashi Ikeda, Takumi Nakamura, Takeo Saito, Atsushi Takata, Takehiko Yokomizo, Nakao Iwata, Tadafumi Kato, Takaoki Kasahara
Mol. Psychiatry, 28, 2848-2856 (2023). 36806390

Health Report

Examination Date / Room / Rack2024-10-21Room:3-CRack:FSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fads1
MGI:1923517		fatty acid desaturase 119Fads1<em2Tkato> endonuclease-mediated mutation 2, Takaoki Kasahara
Fads2
MGI:1930079		fatty acid desaturase 219Fads2<em2Tkato> endonuclease-mediated mutation 2, Takaoki Kasahara

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • decreased body weight (MP:0001262)

  • hyperactivity (MP:0001399)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse a part of Fads1, a part of Fads2, Streptococcus pyogenes crRNA, tracrRNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Psychiatry, 28, 2848–2856 (2023). Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEVELOPER (Dr. Takaoki Kasahara) using the Approval Form.
    DepositorTakaoki Kasahara (RIKEN CBS)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data