Strain Data Sheet

RBRC11813

Strain Information

Image
BRC No.RBRC11813
TypeCRISPR/Cas9 (Transgene)Cartagena
SpeciesMus musculus
Strain nameC57BL/6J-Fads1/Fads2<em1Tkato>
Former Common nameFads(flox/+)
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
GWAS-identified bipolar disorder risk allele in the FADS1/2 gene region links mood episodes and unsaturated fatty acid metabolism in mutant mice.
Hirona Yamamoto, Hyeon-Cheol Lee-Okada, Masashi Ikeda, Takumi Nakamura, Takeo Saito, Atsushi Takata, Takehiko Yokomizo, Nakao Iwata, Tadafumi Kato, Takaoki Kasahara
Mol. Psychiatry, 28, 2848-2856 (2023). doi: 10.1038/s41380-023-01988-2. 36806390

Health Report

Examination Date / Room / Rack2024/06/10Room:3-3Rack:D
2024/03/11Room:3-3Rack:D
2023/12/11Room:3-3Rack:D
2023/09/11Room:3-3Rack:D
2023/06/13Room:3-3Rack:D

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Fads1fatty acid desaturase 119Fads1endonuclease-mediated mutation 1, Takaoki Kasahara
Fads2fatty acid desaturase 219Fads2endonuclease-mediated mutation 1, Takaoki Kasahara
loxPphage P1 loxP19loxP
loxPphage P1 loxP19loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
Detailed phenotype data

Ordering Information

Donor DNAPhage P1 loxP sites, mouse Fads1 genomic DNA, mouse Fads2 genomic DNA, Streptococcus pyogenes crRNA, tracrRNA
Research applicationCre/loxP system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mol. Psychiatry, 28, 2848–2856 (2023).Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEVELOPER (Dr. Takaoki Kasahara) using the Approval Form.
DepositorTakaoki Kasahara (RIKEN CBS)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data