Strain Data Sheet


Strain Information

BRC No.RBRC11808
SpeciesMus musculus
Strain nameC57BL/6-Tg(CAG-hAPP770)Skita Tg(Tek-cre)1Ywa
Former Common nameEC-APP770+
H-2 Haplotype
ES Cell line
Background strain
Strain development
Strain description
Colony maintenance
ReferencesDev. Biol., 230(2):230-42 (2001). 11161575
J. Biol. Chem., 298(6):101880 (2022). 35367207
Int. J. Stroke., 13(6):612-632 (2018). 29786478

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
APP770amyloid-β precursor protein (human)UNAPP770CAG promoter (CMV-IE enhancer, chicken beta-actin promoter, rabbit beta-globin genomic DNA)

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
crePhage P1 Cre recombinaseUNcremouse Tek promoter

Ordering Information

Donor DNACMV IE enhancer, ニワトリ beta-actin promoter, マウス Tie2 プロモーター, ウサギbeta-globin poly A, P1 ファージ loxP配列、Cre recombinase, ヒト Amyloid beta precursor protein 770NL, 大腸菌 ネオマイシン耐性遺伝子
Research applicationMetabolism Research
Mouse Models for Human Disease
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 298(6):101880 (2022). Dev. Biol., 230(2):230-42 (2001).Depositor limits the use of the BIOLOGICAL RESOURCE to not-for-profit institutions. Depositor limits the use of the BIOLOGICAL RESOURCE to academic purposes. For-profit institutions and recipients who intend to use BIOLOGICAL RESOURCE for commercial research purposes shall acquire prior written consent from the Depositor. Recipient shall acquire prior written consent from the Depositor prior to filing an application for patent, or intellectual property or other rights based on the results of research using the BIOLOGICAL RESOURCE. For-profit organizations must contact the DEPOSITOR ( for a licensing contract. If any invention is conceived and reduced to practice by RECIPIENT in the performance of the Research Plan involving the BIOLOGICAL RESOURCE during the term of this MTA, RECIPIENT agrees to promptly inform the invention to DEPOSITOR and the parties will consult each other to determine inventorship and ownership of the invention based on the respective parties contribution to the invention, before filing an application for a patent. In the case of a jointly owned application, the parties will separately enter into a joint application agreement including the sharing of ownership, patent costs and licensing income, as well as the responsible party for the application procedures etc.
DepositorShinobu Kitazume (RIKEN BSI)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. CAGGS MTA (English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data