Strain Data Sheet

RBRC11681

Strain Information

Image
BRC No.RBRC11681
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Ogg1<tm1Yun>
Former Common nameOgg1 KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeposited by Yusaki Nakabeppu, Kyusyu University in 2022. This strain was generated using CCE/EK.CCE ES Cell derived from 129S/SvEv-Gpi1<c> and then mice were backcrossed to C57BL/6J for 44 generations. C57BL/6J congenic strain.
Strain descriptionOgg1 mutant mice. A neo fragment replaced exon 1-3.
Colony maintenance
References
Ogg1 knockout-associated lung tumorigenesis and its suppression by Mth1 gene disruption.
Kunihiko Sakumi, Yohei Tominaga, Masato Furuichi, Ping Xu, Teruhisa Tsuzuki, Mutsuo Sekiguchi, Yusaku Nakabeppu
Cancer Res., 63(5):902-5 (2003). 12615700

Health Report

Examination Date / Room / Rack2025/09/08Room:3-CRack:ISentinel mouse program
2025/06/30Room:3-CRack:ISentinel mouse program
2025/04/21Room:3-CRack:ISentinel mouse program
2025/01/27Room:3-CRack:IAdditional tests
2025/01/20Room:3-CRack:ISentinel mouse program
2024/10/21Room:3-CRack:ISentinel mouse program
2024/04/22Room:3-CRack:ISentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ogg1
MGI:1097693		8-oxoguanine DNA-glycosylase 16Ogg1<tm1Yun> targeted mutation 1, Yusaku Nakabeppu
  • nonpapillary renal cell carcinoma(MedGEN)
    • neo neomycin resistance gene (E. coli)6 mouse RNA polymerase II large subunit promoter

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAmouse RNA polymerase II large subunit promoter, E. coli Neomycin resistant gene, mouse Hprt polyA signal, mouse Ogg1 genomic DNA
    Research applicationCancer Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cancer Res., 63(5):902-5 (2003).
    DepositorYusaku Nakabeppu (Kyushu University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data