Strain Data Sheet

RBRC11679

Strain Information

Image
BRC No.RBRC11679
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S-Nudt1<tm1Yun>
Former Common nameMth1 KO
H-2 Haplotype
ES Cell lineCCE/EK.CCE [129S/SvEv-Gpi1<c>]
Background strain
Appearance
Strain developmentDeposited by Yusaki Nakabeppu, Kyusyu University in 2022. This strain was generated using CCE/EK.CCE ES Cell derived from 129S/SvEv-Gpi1<c> and then mice were backcrossed to C57BL/6J for 41 generations. C57BL/6J congenic strain.
Strain descriptionNudt1 mutant mice. Exon 3 is replaced with a Neo fragment.
Colony maintenance
References
Spontaneous tumorigenesis in mice defective in the MTH1 gene encoding 8-oxo-dGTPase.
T Tsuzuki, A Egashira, H Igarashi, T Iwakuma, Y Nakatsuru, Y Tominaga, H Kawate, K Nakao, K Nakamura, F Ide, S Kura, Y Nakabeppu, M Katsuki, T Ishikawa, M Sekiguchi
Proc. Natl. Acad. Sci. USA, 98(20):11456-61(2001). 11572992

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Nudt1
MGI:109280		nudix hydrolase 15Nudt1<tm1Yun> targeted mutation 1, Yusaku Nakabeppu
neo neomycin resistance gene (E. coli)5

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
Detailed phenotype data

Ordering Information

Donor DNAmouse RNA polymerase II large subunit promoter, E. coli Neomycin resistant gene, mouse Hprt polyA signal, mouse Nudt1 genomic DNA
Research applicationCancer Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 98(20):11456-61(2001).
DepositorYusaku Nakabeppu (Kyushu University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data