Strain Data Sheet

RBRC11571

Strain Information

Image
BRC No.RBRC11571
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Gba2<tm1Rus>/Yhir
Former Common nameGBA2 KO
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Hisako Akiyama in 2021 with permission from Dr. Dagmar Wachten. This strain was generated using ES cells derived from 129S6/SvEv and then backcrossed to C57BL/6J for 10 generations.
Strain descriptionGba2 knockout mice. Exons 5-10 are deleted.
Colony maintenance
References
Mutation of beta-glucosidase 2 causes glycolipid storage disease and impaired male fertility.
Yildiz Y, Matern H, Thompson B, Allegood J C, Warren R L, Ramirez D M, Hammer R E, Hamra F K, Matern S, Russell D W
J. Clin. Invest., 116(11):2985-94 (2006). 17080196

Glucocerebrosidases catalyze a transgalactosylation reaction that yields a newly-identified brain sterol metabolite, galactosylated cholesterol.
Akiyama H, Ide M, Nagatsuka Y, Sayano T, Nakanishi E, Uemura N, Yuyama K, Yamaguchi Y, Kamiguchi H, Takahashi R, Aerts J M F G, Greimel P, Hirabayashi Y
J. Biol. Chem., 295(16):5257-5277 (2020). 32144204

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Gba2
MGI:2654325		glucosidase beta 24Gba2<tm1Rus>
MGI:3691302		targeted mutation 1, David W Russell
  • hereditary spastic paraplegia 46(MedGEN)
    • loxP phage P1 loxP4loxP

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAP1ファージ loxP
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Biol. Chem., 295(16):5257-5277 (2020).
    DepositorHiroyuki Kamiguchi (RIKEN CBS)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data