Strain Data Sheet

RBRC11554

Strain Information

Image
BRC No.RBRC11554
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Bcl2l11<tm1.1Mtto>
Former Common nameBim<f/f>
H-2 Haplotype
ES Cell lineBruce 4 [B6.Cg-Thy1<a>]
Background strain
Appearance
Strain developmentDeposited by Toshitada Takemori, RIKEN in 2021. This strain was generated using Bruce 4 ES cells derived from B6.Cg-Thy1.1. C57BL/6 congenic line. Frt-flanked neo cassette was removed in this strain.
Strain descriptionFloxed Bcl2l11(Bim) mice. A pair of loxP flanks exon 5 of the Bcl2l11(Bim) gene.
Colony maintenance
References
Bim establishes the B cell repertoire from early to late in the immune response.
Sugimoto-Ishige A, Harada M, Tanaka M, Terooatea T, Adachi Y, Takahashi Y, Tanaka T, Burrows P D, Hikida M, Takemori T
Int. Immunol., 33(2):79-90 (2021). 32889526

Health Report

Examination Date / Room / Rack2025/08/18Room:3-5Rack:CSentinel mouse program
2025/06/09Room:3-5Rack:CSentinel mouse program
2025/03/10Room:3-5Rack:CSentinel mouse program
2024/12/09Room:3-5Rack:CSentinel mouse program
2024/09/09Room:3-5Rack:CSentinel mouse program
2024/06/10Room:3-5Rack:CSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Bcl2l11
MGI:1197519		BCL2 like 112Bcl2l11<tm1.1Mtto> targeted mutation 1.1, Toshitada Takemori
Frt yeast FRT (flippase recombination target) site2Frt
loxP phage P1 loxP2loxP

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
Detailed phenotype data

Ordering Information

Donor DNABacterial virus(Enterobacteria phage P1) loxP sites, Saccharomyces cerevisiae FRT sites, mouse Bcl2l11 genomic DNA
Research applicationCre/loxP system
FLP/frt system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Int. Immunol., 33(2):79-90 (2021). In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DepositorToshitada Takemori (RIKEN)
Strain Statusan icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data