Strain Data Sheet


Strain Information

BRC No.RBRC11548
SpeciesMus musculus
Strain nameB6-Ntrk1<em1(E495K)Tkato>/KN2
Former Common nameB6J-Ntrk1 (CRISPR, 268-1); (PM+T)/+
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Tadafumi Kato, RIKEN CBS in 2021. This strain was generated using the CRISPR/Cas9. C57BL/6J genetic background.
Strain descriptionA damaging missense mutation E492K (rs144901788) reported in humans was introduced in the mouse Ntrk1 (TrkA) genomic region.
Colony maintenance
ReferencesSci. Rep., 6:34703 (2016). 27698470
Transl. Psychiatry, 10, 407 (2020). 33235206

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Ntrk1neurotrophic tyrosine kinase, receptor, type 13Ntrk1<em1(E495K)Tkato>endonuclease-mediated mutation 1, Tadafumi Kato

Ordering Information

Donor DNAStreptococcus pyogenes Cas9 mRNA, Streptococcus pyogenes sgRNA, マウス single strand oligo DNA (a part of Ntrk1 gene)
Research applicationMouse Models for Human Disease
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Transl. Psychiatry, 10, 407 (2020).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
DepositorTadafumi Kato (RIKEN)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data