Strain Data Sheet



BRC No.RBRC11431
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6;Cg-Flt1<tm1Msh>
Former Common nameFLT1<TK-/-> mice, FLT1TK<+/-> mice
H-2 Haplotype
ES Cell lineJ1 [129S4/SvJae]
Background strain
Strain developmentDeposited by Masabumi Shibuya, Jobu University in 2021. This strain was generated using J1 (ES Cell) derived from 129S4/SvJae. Mice were backcrossed to C57BL.6 for several generations. Mixed genetic background.
Strain descriptionFlt1 mutant mice lacking kinase domain.
Colony maintenance
ReferencesProc. Natl. Acad. Sci. USA, 95(16):9349-54 (1998). 9689083
Cancer Cell, 2(4):289-300 (2002). 12398893
Cancer Res., 70(20):8211-21 (2010). 20924106
Blood, 108(6):1849-56 (2006). 16709927
Cancer Cell., 27(6):780-96 (2015). 26058077

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Flt1FMS-like tyrosine kinase 15Flt1<tm1Msh>targeted mutation 1, Masabumi Shibuya

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)5


Donor DNAE. coli Neomycin-resistant gene, Mouse FLT1 gene: Intron-16, -17の一部
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc Natl Acad Sci USA., 95(16):9349-54 (1998).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. (from the Deposition time on 2021 year to 2023y.3.31. After that, there is no requirement for this item.)
DepositorMasabumi Shibuya (Jobu University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data