Strain Data Sheet



BRC No.RBRC11291
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Lyn<tm1Tya>
Former Common name
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Strain developmentDeposited by Tadashi Yamamoto, OIST, in 2021. E14 ES Cells were used to generate this strain. Mice were further backcrossed to C57BL/6J for 7 or 8 generations. C57BL/6 congenicc strain.
Strain descriptionLyn knockout mice. Exon 4 of the Lyn gene was replaced with a neo gene.
Colony maintenance
ReferencesImmunity, 3, 549-60 (1995). 7584145
J. Immunol., 158, 2350-2355 (1997). 9036984
J. Exp. Med., 187, 1343-1348 (1998). 9547345

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
LynLYN proto-oncogene, Src family tyrosine kinase4Lyn<tm1Tya>targeted mutation 1, Tadashi Yamamoto

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
GHgrowth hormone polyA (bovine)4GH

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)4mouse phosphoglycerate kinase promoter (PGK promoter)


Donor DNA大腸菌 Neo, マウス PGK-promoter, ウシ growth hormone polyA付
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity 3, 549-60 (1995).
DepositorTadashi Yamamoto (Okinawa Institute of Science and Technology Graduate University (OIST))
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data