Strain Data Sheet

RBRC11285

Strain Information

Image
BRC No.RBRC11285
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Ltb4r1<tm1c(EUCOMM)Hmgu>/Tyoko
Former Common nameBLT1-KO, BLT1<flox/flox>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Takehiko Yokomizo, Juntendo University in 2021. ES cells obtained from EUCOMM were used. Mice were further crossed with CAG-FLPe Tg mice to generate floxed allele. C57BL/6 genetic background.
Strain descriptionFloexed Ltb4r1 mice.
Colony maintenance
References
Leukotriene receptors as potential therapeutic targets.
Takehiko Yokomizo, Motonao Nakamura, Takao Shimizu
J. Clin. Invest., 128, p2691-2701 (2018). 29757196

Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation.
Tomoaki Koga, Fumiyuki Sasaki, Kazuko Saeki, Soken Tsuchiya, Toshiaki Okuno, Mai Ohba, Takako Ichiki, Satoshi Iwamoto, Hirotsugu Uzawa, Keiko Kitajima, Chikara Meno, Eri Nakamura, Norihiro Tada, Yoshinori Fukui, Junichi Kikuta, Masaru Ishii, Yukihiko Sugimoto, Mitsuyoshi Nakao, Takehiko Yokomizo
Cell Mol. Immunol., 18(6):1437-1449 (2020). 33037399

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site14Frt
Ltb4r1
MGI:1309472		leukotriene B4 receptor 114Ltb4r1<tm1c(EUCOMM)Hmgu> targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH
loxP phage P1 loxP14loxP

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • decreased inflammatory response (MP:0001876)
    • Detailed phenotype data

    Ordering Information

    Donor DNAバクテリオファージP1 loxP, Saccharomyces cerevisiae FRT
    Research applicationCre/loxP system
    FLP/frt system
    Immunology and Inflammation Research
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Mol Immunol. 2020 Oct 9. doi: 10.1038/s41423-020-00559-7. The RECIPIENT must contact the DEPOSITOR in the case of a application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT of RBRC11285 shall acknowledge the EUCOMM as the Provider of the ES cells to generate KO mice.
    DepositorTakehiko Yokomizo (Juntendo University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data