Strain Data Sheet

RBRC11284

Strain Information

Image
BRC No.RBRC11284
TypeCRISPR/Cas9Cartagena
SpeciesMus musculus
Strain nameC57BL/6J-Cant1<em1Tfric>
Former Common nameCant1 KO22
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeposited by Tatsuya Furuichi, Iwate University in 2021. C57BL/6J genetic background.
Strain descriptionCant1 mutant mice generated by the CRISPR/Cas9. 10 bp deletion at exon 3 of the Cant1 gene. Homozygous mutants are growth-retarded and infertile.
Colony maintenance
References
CANT1 deficiency in a mouse model of Desbuquois dysplasia impairs glycosaminoglycan synthesis and chondrocyte differentiation in growth plate cartilage.
Kodama K, Takahashi H, Oiji N, Nakano K, Okamura T, Niimi K, Takahashi E, Guo L, Ikegawa S, Furuichi T
FEBS Open Bio 10,1096-1103 (2020). 32277574

Health Report

Examination Date / Room / Rack2023/07/24Room:3-CRack:C
2023/04/24Room:3-CRack:C
2023/01/23Room:3-CRack:C
2022/10/25Room:3-CRack:C

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cant1calcium activated nucleotidase 111Cant1endonuclease-mediated mutation 1, Tatsuya Furuichi
  • Desbuquois dysplasia 1(MedGEN)

  • epiphyseal dysplasia, multiple, 7(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. FEBS Open Bio 10,1096-1103 (2020). For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and condition of use of it with DEPOSITOR and must obtain a prior written the DEPOSITOR.
    DepositorTatsuya Furuichi (Iwate University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: CRISPR/Cas9 genome edited bioresources (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data