Strain Data Sheet

RBRC11206

Strain Information

Image
BRC No.RBRC11206
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S2-Ramp1<tm1.2Tsuj>
Former Common nameRamp1 flox/+
H-2 Haplotype
ES Cell lineD3 [129S2/SvPas]
Background strain
Appearance
Strain developmentDeveloped and deposited by Kazutake Tsujikawa, Osaka University in 2020. ES cells derived from 129/Sv. Mice were backcrossed to C57BL/6 for 12 generations. C57BL/6 congenic line.
Strain descriptionRAMP1 (receptor activity-modifying protein 1) floxed mice. A pair of loxP flanks exon 2.
Colony maintenance
References
Hypertension and dysregulated proinflammatory cytokine production in receptor activity-modifying protein 1-deficient mice.
Kazutake Tsujikawa, Katsutoshi Yayama, Tamon Hayashi, Hiroaki Matsushita, Taijiro Yamaguchi, Tomomi Shigeno, Yusuke Ogitani, Megumi Hirayama, Tetsuya Kato, So-ichiro Fukada, Shingo Takatori, Hiromu Kawasaki, Hiroshi Okamoto, Masahito Ikawa, Masaru Okabe, Hiroshi Yamamoto
Proc. Natl. Acad. Sci. USA, 104, 16702-16707 (2007). 17923674

Health Report

Examination Date / Room / Rack2025-11-17Room:3-CRack:HSentinel mouse program
2025-09-08Room:3-CRack:HSentinel mouse program
2025-06-30Room:3-CRack:HSentinel mouse program
2025-04-21Room:3-CRack:HSentinel mouse program
2025-01-20Room:3-CRack:HSentinel mouse program
2024-10-21Room:3-CRack:HSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ramp1
MGI:1858418		receptor (calcitonin) activity modifying protein 11Ramp1<tm1.2Tsuj> targeted mutation 1.2, Kazutake Tsujikawa
loxP phage P1 loxP1loxP
loxP phage P1 loxP1loxP

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • normal phenotype (MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, Mouse Ramp1 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE shall obtain a prior written consent on use of it from the DEPOSITOR. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 104, 16702-16707 (2007). RECIPIENT which wants to use the BIOLOGICAL RESOURCE for the purpose other than education or not-for-profit research is requested to enter into a Material Transfer Agreement with Osaka University. The RECIPIENT which wants to use the BIOLOGICAL RESOURCE even after five years must obtain a written consent from the DEPOSITOR again.
    DepositorKazutake Tsujikawa (Osaka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)
    Co-creation Bureau, Osaka University HP
    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data