Strain Information | |
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Image | |
BRC No. | RBRC11202 |
Type | Targeted Mutation![]() |
Species | Mus musculus |
Strain name | STOCK Slc12a2<tm1.1(tetO)Kftnk> |
Former Common name | NKCC1 tetO knockin |
H-2 Haplotype | |
ES Cell line | G0G1 |
Background strain | |
Appearance | |
Strain development | Deposited by Kenji Takana, Keio University in 2021. Mixed genetic background. |
Strain description | TetO cassette knock in at the Slc12a2 genomic area between its promoter and coding sequence. |
Colony maintenance | |
References | Time-controllable Nkcc1 knockdown replicates reversible hearing loss in postnatal mice. Watabe T, Xu M, Watanabe M, Nabekura J, Higuchi T, Hori K, Sato M P, Nin F, Hibino H, Ogawa K, Masuda M, Tanaka K F Sci. Rep., 7(1):13605. (2017). 29051615Oligodendrocytic Na+-K+-Cl- co-transporter 1 activity facilitates axonal conduction and restores plasticity in the adult mouse brain. Yoshihiko Yamazaki, Yoshifumi Abe, Satoshi Fujii, Kenji F Tanaka Nat. Commun., 12(1) 5146 (2021). 34446732 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Frt | yeast FRT (flippase recombination target) site | 18 | Frt | ||||
Slc12a2 MGI:101924 | solute carrier family 12, member 2 | 18 | Slc12a2<tm1.1(tetO)Kftnk> | targeted mutation 1.1, Kenji Tanaka | |||
loxP | phage P1 loxP | 18 | loxP | ||||
loxP | phage P1 loxP | 18 | loxP | ||||
tetO | tetracycline operator (E. coli) | 18 | tetO |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, yeast FRT (flippase recombination target) site, tetracycline operator (E. coli), Cytomegalovirus CMV minimum promoter, mouse Slc12a2 genomic DNA |
Research application | Cre/loxP system FLP/frt system Tet system |
Specific Term and Conditions | No specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.) |
Depositor | Kenji Tanaka (Keio University) |
Strain Status | ![]() |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |