Strain Data Sheet



BRC No.RBRC11161
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6N-Arg1<tm1.1(KikGR)Ksho>
Former Common nameArg1-KikGR
H-2 Haplotype
ES Cell lineJM8A3.N1 [C57BL/6N-A<tm1Brd>]
Background strain
Strain developmentDeveloped by Tsuneyasu Kaisho, Research Center for Allergy and Immunologuy, RIKEN around 2009.
Strain descriptionArginase 1, ARG1, is an enzyme in urea cycle and generates ornithine and urea from arginine. In type 2 inflammation, ARGI expression is known to be increased in macrophages. ArgI-KikGR mice were generated by knocking a gene encoding a photoconvertible green-to-red fluorescent protein KikGR into the murine ArgI gene locus.
Colony maintenance

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Arg1arginase, liver10Arg1<tm1.1(KikGR)Ksho>targeted mutation 1.1, Tsuneyasu Kaisho

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Frtyeast FRT (flippase recombination target) site10Frt

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
GHGrowth hormone polyA (Bovine)10GH

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
kikGRGreen-Red Fluorescent Protein (Favia favus)10kikGR


Donor DNAFavia favus KikGR cDNA, Bos taurus bGH polyA, Saccharomyces cerevisiae FRT site, mouse Arg1 genomic DNA
Research applicationFLP/frt system
Fluorescent Proteins/lacZ System
Immunology and Inflammation Research
Metabolism Research
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 後日指定The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit organization for a not-for-profit research. For use of the BIOLOGICAL RESOURCE by a for-profit organization, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and a right holder for phKikGRl-S1, Medical & Biological Laboratories (MBL) Co., Ltd., and must obtain a prior written consent from the DEPOSITOR and MBL. The RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEVELOPER of the kikGR using Approval form (form V) (Lab Contact: Laboratory for Cell Function Dynamics, RIKEN CBS:
DepositorTsuneyasu Kaisho (RIKEN)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-
Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Approval form (form V) from the developer (English)
  5. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data