Strain Data Sheet

RBRC11114

Strain Information

Image
BRC No.RBRC11114
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Larp7<tm1Ymat>
Former Common nameLarp7-KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Yasuhisa Matsui, Tohoku University, in 2012. Mice were generated using E14-1 ES cells derived from 129P2/OlaHsd. Mixed genetic background with C57BL/6.
Strain descriptionLarp7 knockout mice. Exons 2-8 were replaced with a floxed pgk-neo cassette via homologous recombination.
Colony maintenance
References
Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.
Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte J C, Matsui Y
Genes Dev., 26(22):2477-82 (2012). 23154982

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Larp7La ribonucleoprotein 7, transcriptional regulator3Larp7targeted mutation 1, Yasuhisa Matsui
  • microcephalic primordial dwarfism, Alazami type(MedGEN)
    • loxPphage P1 loxP3loxP
  • microcephalic primordial dwarfism, Alazami type(MedGEN)
    • loxPphage P1 loxP3loxP
  • microcephalic primordial dwarfism, Alazami type(MedGEN)
    • neoneomycin resistance gene (E. coli)3mouse phosphoglycerate kinase promoter (PGK promoter)
  • microcephalic primordial dwarfism, Alazami type(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promo (Pgk1 promoter), E. coli neomycin resistant gene, polyA付加配列
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev. 2012 Nov 15;26(22):2477-82.
    DepositorYasuhisa Matsui (Tohoku University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data