Strain Data Sheet

RBRC11114

Strain Information

Image
BRC No.RBRC11114
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;129P2-Larp7<tm1Ymat>
Former Common nameLarp7-KO
H-2 Haplotype
ES Cell lineE14.1 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeveloped by Yasuhisa Matsui, Tohoku University, in 2012. Mice were generated using E14-1 ES cells derived from 129P2/OlaHsd. Mixed genetic background with C57BL/6.
Strain descriptionLarp7 knockout mice. Exons 2-8 were replaced with a floxed pgk-neo cassette via homologous recombination.
Colony maintenance
References
Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells.
Okamura D, Maeda I, Taniguchi H, Tokitake Y, Ikeda M, Ozato K, Mise N, Abe K, Noce T, Izpisua Belmonte J C, Matsui Y
Genes Dev., 26(22):2477-82 (2012). 23154982

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Larp7
MGI:107634		La ribonucleoprotein 7, transcriptional regulator3Larp7<tm1Ymat> targeted mutation 1, Yasuhisa Matsui
  • microcephalic primordial dwarfism, Alazami type(MedGEN)
    • loxP phage P1 loxP3loxP
    loxP phage P1 loxP3loxP
    neo neomycin resistance gene (E. coli)3 mouse phosphoglycerate kinase promoter (PGK promoter)

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, mouse phosphoglycerate kinase promo (Pgk1 promoter), E. coli neomycin resistant gene, polyA付加配列
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes Dev. 2012 Nov 15;26(22):2477-82.
    DepositorYasuhisa Matsui (Tohoku University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data