Strain Information | |
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Image | |
BRC No. | RBRC11093 |
Type | Transgene![]() |
Species | Mus musculus |
Strain name | C57BL/6-Tg(RP24-310A6/Luc)2MftymMfuku |
Former Common name | BDNF-Luc |
H-2 Haplotype | |
ES Cell line | RENKA [C57BL/6NCrlCrlj] |
Background strain | |
Appearance | |
Strain development | Deposited by Mamoru Fukuchi in 2020. C57BL/6 genetic background. |
Strain description | Bac transgenic mice expressing Luc2 under the control of the BDNF gene promoter. Luc2 was inserted at exon IX of the Bdnf gene. |
Colony maintenance | |
References | Neuromodulatory effect of Galphas- or Galphaq-coupled G-protein-coupled receptor on NMDA receptor selectively activates the NMDA receptor/Ca2+/calcineurin/cAMP response element-binding protein-regulated transcriptional coactivator 1 pathway to effectively induce brain-derived neurotrophic factor expression in neurons. Fukuchi M, Tabuchi A, Kuwana Y, Watanabe S, Inoue M, Takasaki I, Izumi H, Tanaka A, Inoue R, Mori H, Komatsu H, Takemori H, Okuno H, Bito H, Tsuda M J. Neurosci., 35(14):5606-24 (2015). 25855176Visualizing changes in brain-derived neurotrophic factor (BDNF) expression using bioluminescence imaging in living mice. Fukuchi M, Izumi H, Mori H, Kiyama M, Otsuka S, Maki S, Maehata Y, Tabuchi A, Tsuda M Sci. Rep., 7(1):4949 (2017). 28694523 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
luc | Photinus pyralis Luciferase | UN | luc |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Photinus pyralis Luciferase (Promega社:luc2), mouse BDNF genomic DNA (BAC clone RP24-310A6) |
Research application | |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 35(14):5606-24 (2015). Sci. Rep., 7(1):4949 (2017).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for institution fora not-for-profit research. |
Depositor | Mamoru Fukuchi (Takasaki University of Health and Welfare) |
Strain Status | ![]() |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |