Strain Data Sheet


Strain Information

BRC No.RBRC10971
TypeTargeted Mutation CongenicCartagena
SpeciesMus musculus
Strain nameB6.Cg-Serpinh1<tm1Kzn>
Former Common nameHsp47 +/-
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Strain developmentDeveloped by Kazuhiro Nagata, Kyoto University in 2000. E14 ES cells derived from 129P2/OlaHsd were used. C57BL/6 congenic strain by backcrossing over 21 generations.
Strain descriptionSerpinh1 (Hsp47) knockout mice. Exon 4 was replaced with the Neo gene cassette.
Colony maintenance
ReferencesJ. Cell Biol. 150(6):1499-506 (2000). 10995453

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Serpinh1serine (or cysteine) peptidase inhibitor, clade H, member 17Serpinh1<tm1Kzn>targeted mutation 1, Kazuhiro Nagata

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)7herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
SV40 polyA signal7

Ordering Information

Donor DNAHerpes Simplex virus (HSV) Thymidine kinase (TK) promoter, E. coli Neomycin resistant gene, SV40 polyA signal, mouse Serpinh1 genomic DNA
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Cell Biol. 150(6):1499-506 (2000).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorKazuhiro Nagata (Kyoto Sangyo University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data