Strain Data Sheet
RBRC10904
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC10904 |
| Type | Transgene |
| Species | Mus musculus |
| Strain name | 129.Cg-Tg(Th-MYCN)41WawKkad |
| Former Common name | Th-MYCN, TH-MYCN |
| H-2 Haplotype | |
| ES Cell line | |
| Background strain | |
| Appearance | |
| Strain development | Deposited by Welliam A. Weiss in 2020. |
| Strain description | The rat tyrosine hydrolase promoter directs expression of human v-myc myelocytomatosis viral related oncogene, neuroblastoma derived (avian) (MYCN) to migrating cells of the neural crest during early development. |
| Colony maintenance | |
| References | Targeted expression of MYCN causes neuroblastoma in transgenic mice. Weiss W A, Aldape K, Mohapatra G, Feuerstein B G, Bishop J M EMBO J., 16(11):2985-95 (1997). 9214616 |
Health Report | |
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| Examination Date / Room / Rack | 2024/05/27Room:4-CRack:KSentinel mouse program 2024/02/26Room:4-CRack:KSentinel mouse program |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| HBB2 | rabbit beta-globin Intron (enhancer) | UN | HBB2 | ||||
| MYCN | Human MYCN cDNA | UN | MYCN | rat tyrosine hydroxylase (TH) promoter | |||
| Herpes simplex virus Thymidine kinase gene terminator/poly(A) sequence | UN | ||||||
Phenotype | |
|---|---|
| Phenotype annotation from literatures by Mammalian phenotype ontology | |
| Detailed phenotype data | |
Ordering Information | |
|---|---|
| Donor DNA | Rat Tyrosine Hydroxylase Promoter, Rabbit Beta-Globin Intron (enhancer), Human MYCN cDNA, Herpes simplex virus Thymidine kinase gene terminator/poly(A) sequence |
| Research application | Cancer Research |
| Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. EMBO J., 16(11):2985-95 (1997). Limitation of recipients of the BIOLOGICAL RESOURCE to not-for-profit institutions, limitation of the use to academic research purposes for-profit institutions or use for commercial research purposesshall acquire a prior written consent from the Depositor. |
| Depositor | William Weiss (The University of California, San Francisco) |
| Strain Status |  Frozen embryos Frozen sperm |
| Strain Availability | Recovered litters from cryopreserved embryos (2 to 4 months) Cryopreserved embryos (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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| No Data |