Strain Data Sheet

RBRC10854

Strain Information

Image
BRC No.RBRC10854
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6N-Ctsc<tm1.1Ike>
Former Common nameCatC tetO knockin
H-2 Haplotype
ES Cell lineRENKA [C57BL/6NCrlCrlj]
Background strain
Appearance
Strain developmentDeveloped by Kazuhiro Ikenaka at National Institute for Physiological Sciences in collaboration with Kenji Sakimura at Niigata University. RENKA ES cells derived from C57BL/6N were used to generate this strain. C57BL/6N background. Homozygous mice are viable and fertile.
Strain descriptionKnockin mice in which a STOP-tetO cassette was placed upstream of the translation initiation site of the Ctsc (Cathepsin C) gene.Inserted DNA cassette contains loxP-FRT-Neo-poly A-FRT-tetO-loxP. Frt-flanked Neo-polyA cassette was removed by Flp.
Colony maintenance
References
The balance between cathepsin C and cystatin F controls remyelination in the brain of Plp1-overexpressing mouse, a chronic demyelinating disease model.
Shimizu T, Wisessmith W, Li J, Abe M, Sakimura K, Chetsawang B, Sahara Y, Tohyama K, Tanaka K F, Ikenaka K
Glia, 65(6):917-930 (2017). 28251676

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ctsccathepsin C7Ctsctargeted mutation 1.1, Kazuhiro Ikenaka
  • Haim-Munk syndrome(MedGEN)

  • Papillon-Lefevre disease(DisGeNET, MedGEN)

  • periodontitis, aggressive 1(MedGEN)
    • Frtyeast FRT (flippase recombination target) site7Frt
  • Haim-Munk syndrome(MedGEN)

  • Papillon-Lefevre disease(DisGeNET, MedGEN)

  • periodontitis, aggressive 1(MedGEN)
    • loxPphage P1 loxP7loxP
  • Haim-Munk syndrome(MedGEN)

  • Papillon-Lefevre disease(DisGeNET, MedGEN)

  • periodontitis, aggressive 1(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNA大腸菌 tetracycline operator site 酵母 FRT CMV 最小プロモーター バクテリオファージP1 loxP
    Research applicationCre/loxP system
    FLP/frt system
    Tet system
    Specific Term and ConditionsNo specific terms and conditions. (The DEPOSITOR waives its own rights under any patents, intellectual property, or other proprietary rights with respect to the results to be obtained by use of the BIOLOGICAL RESOURCE.)
    DepositorNobuhiko Ohno (National Institute for Physiological Sciences)
    Strain Statusan icon for Frozen embryosFrozen embryos
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data