Strain Data Sheet

RBRC10743

Strain Information

Image
BRC No.RBRC10743
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6J-Tg(Mapt-neo,-YC2.60)#Ito
Former Common nametLSL-YC2.60
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Shigeyoshi Itohara at RIKEN. A BAC transgenic DNA construct was injected to C57BL/6J. C57BL/6J genetic background.
Strain descriptionTransgenic mice expressing YC2.60 under the control of Tau promoter and Cre recombinase.
Colony maintenance
References
Excitatory Neuronal Hubs Configure Multisensory Integration of Slow Waves in Association Cortex.
Kuroki S, Yoshida T, Tsutsui H, Iwama M, Ando R, Michikawa T, Miyawaki A, Ohshima T, Itohara S
Cell Rep., 22(11):2873-2885 (2018). 29539417

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
SV40 Intron polyAUN
  • frontotemporal dementia(DisGeNET, MedGEN)

  • late-onset Parkinson disease(MedGEN)

  • Pick disease(DisGeNET, MedGEN)
    • more 2 Diseases
  • progressive supranuclear palsy-parkinsonism syndrome(MedGEN)

  • supranuclear palsy, progressive, 1(MedGEN)
    • Actbchicken beta-actin polyAUNActb
  • frontotemporal dementia(DisGeNET, MedGEN)

  • late-onset Parkinson disease(MedGEN)

  • Pick disease(DisGeNET, MedGEN)
    • more 2 Diseases
  • progressive supranuclear palsy-parkinsonism syndrome(MedGEN)

  • supranuclear palsy, progressive, 1(MedGEN)
    • WPREWoodchuck hepatitis virus posy-transcriptional regulatory element (WPRE)UNWPRE
  • frontotemporal dementia(DisGeNET, MedGEN)

  • late-onset Parkinson disease(MedGEN)

  • Pick disease(DisGeNET, MedGEN)
    • more 2 Diseases
  • progressive supranuclear palsy-parkinsonism syndrome(MedGEN)

  • supranuclear palsy, progressive, 1(MedGEN)
    • YC2.60Yellow Cameleon 2.60 (Aequorea victoria ECFP cDNA, Xenopus laevis calm2 cDNA, calmodulin (CaM)-binding peptide (rabbit skeletal muscle myosin light chain kinase (MLCK) cDNA), circularly permuted form of the Venus yellow fluorescent protein cDNA)UNYC2.60
  • frontotemporal dementia(DisGeNET, MedGEN)

  • late-onset Parkinson disease(MedGEN)

  • Pick disease(DisGeNET, MedGEN)
    • more 2 Diseases
  • progressive supranuclear palsy-parkinsonism syndrome(MedGEN)

  • supranuclear palsy, progressive, 1(MedGEN)
    • loxPphage P1 loxPUNloxP
  • frontotemporal dementia(DisGeNET, MedGEN)

  • late-onset Parkinson disease(MedGEN)

  • Pick disease(DisGeNET, MedGEN)
    • more 2 Diseases
  • progressive supranuclear palsy-parkinsonism syndrome(MedGEN)

  • supranuclear palsy, progressive, 1(MedGEN)
    • neoneomycin resistance gene (E. coli)UNmouse phosphoglycerate kinase promoter (PGK promoter)
  • frontotemporal dementia(DisGeNET, MedGEN)

  • late-onset Parkinson disease(MedGEN)

  • Pick disease(DisGeNET, MedGEN)
    • more 2 Diseases
  • progressive supranuclear palsy-parkinsonism syndrome(MedGEN)

  • supranuclear palsy, progressive, 1(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAmouse Tau promoter, Phage P1 loxP sites, mouse pgk promoter, E. coli neomycin resistance gene, Yellow Cameleon 2.60 (Aequorea victoria ECFP cDNA, Xenopus laevis calm2 cDNA, calmodulin (CaM)-binding peptide (rabbit skeletal muscle myosin light chain kinase (MLCK) cDNA), circularly permuted form of the Venus yellow fluorescent protein cDNA), Woodchuck hepatitis virus posttranscriptional regulatory element (WPRE), SV40 intron polyA, chicken polyA
    Research applicationCre/loxP system
    Fluorescent Proteins/lacZ System
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Cell Rep., 22(11):2873-2885 (2018).In publishing the research results obtained by use of the BIOLOGICAL RESOURCE containing Venus, an acknowledgment to Dr. Atsushi Miyawaki and a citation of the following literature(s) designated by the DEPOSITOR are requested.
    Nat. Biotechnol., 20, 87-90 (2002).
    DepositorShigeyoshi Itohara (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-
    Sequence of Y2.60

    BRC mice in Publications

    No Data