Strain Data Sheet

RBRC10712

Strain Information

Image
BRC No.RBRC10712
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Ntng2<tm1Ito>
Former Common nameNtng2-KO
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeposited by Shigeyoshi Itohara, RIKEN Brain Science Institute. E14 ES cells derived from 129P2/ola were used.
Strain descriptionNtng2 (netrin G2) knockout mice. 5’UTR and part of coding regions were replaced with loxP.
Colony maintenance
References
Netrin-G/NGL complexes encode functional synaptic diversification.
Matsukawa H, Akiyoshi-Nishimura S, Zhang Q, Lujan R, Yamaguchi K, Goto H, Yaguchi K, Hashikawa T, Sano C, Shigemoto R, Nakashiba T, Itohara S
J. Neurosci., 34(47) 15779-92 (2014). 25411505

Axonal netrin-Gs transneuronally determine lamina-specific subdendritic segments.
Nishimura-Akiyoshi S, Niimi K, Nakashiba T, Itohara S
Proc. Natl. Acad. Sci. USA, 104(37):14801-6 (2007). 17785411

Health Report

Examination Date / Room / Rack2024/06/10Room:3-3Rack:C
2024/03/11Room:3-3Rack:C
2023/12/11Room:3-3Rack:C
2023/09/11Room:3-3Rack:C
2023/06/13Room:3-3Rack:C
2023/03/13Room:3-3Rack:C
2023/01/10Room:3-3Rack:C
2022/12/12Room:3-3Rack:C

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Ntng2netrin G22Ntng2targeted mutation 1, Shigeyoshi Itohara
  • neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia(MedGEN)
    • loxPphage P1 loxP2loxP
  • neurodevelopmental disorder with behavioral abnormalities, absent speech, and hypotonia(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP site, mouse Ntng2 genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA. 104(37):14801-6 (2007).
    DepositorShigeyoshi Itohara (RIKEN)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data