Strain Data Sheet

RBRC10600

Strain Information

Image
BRC No.RBRC10600
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129P2-Adcy1<tm1Ito>
Former Common nameAC1-flox, Adcy1-flox
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Appearance
Strain developmentDeposited by Shigeyoshi Itohara, RIKEN Center for Brain Science. E14 ES cells derived from 129P2 was used. Mice were maintained by crossing to C57BL/6J for more than 10 generations. C57BL/6 congenic strain.
Strain descriptionFloxed mice for Adcy1 (adenylate cyclase 1). Exon 1 was flanked by a pair of loxP.
Colony maintenance
References
Cortical adenylyl cyclase 1 is required for thalamocortical synapse maturation and aspects of layer IV barrel development.
Iwasato T, Inan M, Kanki H, Erzurumlu R S, Itohara S, Crair M C
J. Neurosci., 28(23): 5931-5943 (2008). 18524897

Health Report

Examination Date / Room / Rack2024/04/08Room:3-BRack:B
2024/01/09Room:3-BRack:B
2023/10/10Room:3-BRack:B

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Adcy1adenylate cyclase 111Adcy1targeted mutation 1, Shigeyoshi Itohara
  • autosomal recessive nonsyndromic hearing loss 44(MedGEN)
    • Frtyeast FRT (flippase recombination target) site11Frt
  • autosomal recessive nonsyndromic hearing loss 44(MedGEN)
    • loxPphage P1 loxP11loxP
  • autosomal recessive nonsyndromic hearing loss 44(MedGEN)
    • loxPphage P1 loxP11loxP
  • autosomal recessive nonsyndromic hearing loss 44(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAyeast FRT (flippase recombination target) site, phage P1 loxP sites, mouse Adcy1 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28(23): 5931-5943 (2008).
    DepositorShigeyoshi Itohara (RIKEN CBS)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityCryopreserved sperm (within 1 month)
    Live mouse (3 to 6 months)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data