Strain Data Sheet
RBRC10583
Strain Information | |
|---|---|
| Image | |
| BRC No. | RBRC10583 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | C57BL/6N-Sem1<tm1.1Smta> |
| Former Common name | Sem1 KO |
| H-2 Haplotype | |
| ES Cell line | RENKA [C57BL/6NCrlCrlj] |
| Background strain | |
| Appearance | |
| Strain development | Developed by Jun Hamazaki, The University of Tokyo in 2011. RENKA ES cells derived from C57BL/6N were used. Mice were further backcrossed to C57BL/6N for more than 6 generations. |
| Strain description | Sem1 (SEM1, 26S proteasome complex subunit) knockout mice. Exon 2 of the Sem1 gene are deleted. Homozygous mutants are embryonically lethal. |
| Colony maintenance | |
| References | |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |||||||
|---|---|---|---|---|---|---|---|
| Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
| Sem1 | SEM1, 26S proteasome complex subunit | 6 | Sem1 | targeted mutation 1.1, Shigeo Murata | |||
| loxP | phage P1 loxP | 6 | loxP | ||||
Phenotype | |
|---|---|
| Annotation by Mammalian phenotyhpe ontology | |
| Detailed phenotype data | |
Ordering Information | |
|---|---|
| Donor DNA | Phage P1 loxP site, mouse Sem1 genomic DNA |
| Research application | |
| Specific Term and Conditions | In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. |
| Depositor | Shigeo Murata (The University of Tokyo) |
| Strain Status |  Live mice Frozen sperm |
| Strain Availability |  Recovery and QC required prior to distributionCryopreserved sperm (within 1 month) |
| Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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Arun Prakash Mishra, Suzanne A. Hartford, Sounak Sahu, Kimberly Klarmann, Rajani Kant Chittela, Kajal Biswas, Albert B. Jeon, Betty K. Martin, Sandra Burkett, Eileen Southon, Susan Reid, Mary E. Albaugh, Baktiar Karim, Lino Tessarollo, Jonathan R. Keller, Shyam K. Sharan BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at replication-induced and meiotic DNA double strand breaks Nature Communications 13 (2022) 35365640 |