Strain Data Sheet

RBRC10478

Strain Information

Image
BRC No.RBRC10478
TypeSpontaneous Mutation Congenic
SpeciesMus musculus
Strain nameC3H/HeJ-+/ter
Former Common nameC3H-ter
H-2 Haplotype
ES Cell line
Background strainC3H/HeJ
Appearance
Strain development
Strain description
Colony maintenance
References
A recessive mutation (ter) causing germ cell deficiency and a high incidence of congenital testicular teratomas in 129/Sv-ter mice.
Noguchi T, Noguchi M
J. Natl. Cancer Inst., 75(2):385-92 (1985). 3860691

The ter mutation responsible for germ cell deficiency but not testicular nor ovarian teratocarcinogenesis in ter / ter congenic mice.
Motoko Noguchi, Chiaki Watanabe, Takashi Kobayashi, Miho Kuwashima, Takayuki Sakurai, Hideki Katoh, Kazuo Moriwaki
Dev. Growth Differ., 38, 59-69 (1996). 37282297

Health Report

Examination Date / Room / Rack2023/02/27Room:4-BRack:F
2022/11/29Room:4-BRack:F

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Dnd1DND microRNA-mediated repression inhibitor 118Dnd1teratoma

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal Sertoli cell morphology(MP:0002784)

  • abnormal spermatogenesis(MP:0001156)

  • absent germ cells(MP:0004806)

  • absent oocytes(MP:0004805)

  • decreased Sertoli cell number(MP:0005250)
    • more 6 phenotypes
  • decreased corpora lutea number(MP:0002680)

  • increased Leydig cell number(MP:0001152)

  • male infertility(MP:0001925)

  • small ovary(MP:0001127)

  • small seminiferous tubules(MP:0001153)

  • small testis(MP:0001147)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorToshinobu Tokumoto (Shizuoka University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data