Strain Information | |
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Image | |
BRC No. | RBRC10463 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6-Itgb3bp<tm1.1tfw>/Yuwa |
Former Common name | CenpR KO B6 |
H-2 Haplotype | |
ES Cell line | |
Background strain | |
Appearance | |
Strain development | Developed by Tatsuo Fukagawa, Osaka University, and deposited by Yuichi Wakabayashi, Chiba Cancer Center, in 2018. ES cells derived from C57BL/6J were used. C57BL/6J genetic background. Crossing to a Rosa-cre line, a DNA fragment flanked by loxP was removed. Y choromosome is from C57BL/6J. |
Strain description | Itgb3bp (integrin beta 3 binding protein (beta3-endonexin), CenpR) knockout mice. Homozygous mutants are grossly normal. Exon 4 of the Itgb3bp was deleted. |
Colony maintenance | |
References | CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model. Okumura K, Kagawa N, Saito M, Yoshizawa Y, Munakata H, Isogai E, Fukagawa T, Wakabayashi Y Cancer Sci., 108(11):2142-2148 (2017). 28795467 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Itgb3bp | integrin beta 3 binding protein (beta3-endonexin) | 4 | Itgb3bp | targeted mutation 1.1, Tatsuo Fukagawa | |||
loxP | phage P1 loxP | 4 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | Phage P1 loxP site, mouse Itgb3bp genomic DNA |
Research application | Cre/loxP system |
Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
Depositor | Yuichi Wakabayashi (Chiba Cancer Center) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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No Data |