Strain Data Sheet

RBRC10463

Strain Information

Image
BRC No.RBRC10463
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6-Itgb3bp<tm1.1tfw>/Yuwa
Former Common nameCenpR KO B6
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain developmentDeveloped by Tatsuo Fukagawa, Osaka University, and deposited by Yuichi Wakabayashi, Chiba Cancer Center, in 2018. ES cells derived from C57BL/6J were used. C57BL/6J genetic background. Crossing to a Rosa-cre line, a DNA fragment flanked by loxP was removed. Y choromosome is from C57BL/6J.
Strain descriptionItgb3bp (integrin beta 3 binding protein (beta3-endonexin), CenpR) knockout mice. Homozygous mutants are grossly normal. Exon 4 of the Itgb3bp was deleted.
Colony maintenance
References
CENP-R acts bilaterally as a tumor suppressor and as an oncogene in the two-stage skin carcinogenesis model.
Okumura K, Kagawa N, Saito M, Yoshizawa Y, Munakata H, Isogai E, Fukagawa T, Wakabayashi Y
Cancer Sci., 108(11):2142-2148 (2017). 28795467

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Itgb3bpintegrin beta 3 binding protein (beta3-endonexin)4Itgb3bptargeted mutation 1.1, Tatsuo Fukagawa
loxPphage P1 loxP4loxP

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
  • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP site, mouse Itgb3bp genomic DNA
    Research applicationCre/loxP system
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorYuichi Wakabayashi (Chiba Cancer Center)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    BRC mice in Publications

    No Data