Strain Data Sheet

RBRC10448

Strain Information

Image
BRC No.RBRC10448
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Apba1<tm1Amor>/Tsuz
Former Common nameX11/mint 1 -KO mice
H-2 Haplotype
ES Cell lineCCE28 [129/Sv]
Background strain
Appearance
Strain developmentDeposited by Toshiharu Suzuki, Hokkaido University in 2018. This mutated allele was originally generated by Otsuka Pharmaceutical Co., Ltd. using ES cells derived from 129/SV. This strain was further backcrossed to C57BL/6J for 10 generations by the depositor.
Strain descriptionApba1 (amyloid beta (A4) precursor protein binding, family A, member 1; X11/mint 1) knockout mice. Homozygous mutants are fertile, but their littermate size is small (3 to 5 pups per litter). Heterozygous mice are used for breeding.
Colony maintenance
References
X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in brain.
Saito Y, Sano Y, Vassar R, Gandy S, Nakaya T, Yamamoto T, Suzuki T
J. Biol. Chem., 283, 35763-35771 (2008). 18845544

Alteration of methamphetamine-induced striatal dopamine release in mint-1 knockout mice.
Mori A, Okuyama K, Horie M, Taniguchi Y, Wadatsu T, Nishino N, Shimada Y, Miyazawa N, Takeda S, Niimi M, Kyushiki H, Kondo M, Mitsumoto Y
Neurosci. Res., 43, 251-257 (2002). 12103443

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Apba1amyloid beta precursor protein binding family A member 119Apba1targeted mutation 1, Atsushi Mori
neoneomycin resistance gene (E. coli)19herpes simplex virus thymidine kinase promoter (HSV tk promoter)

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal behavior(MP:0004924)

  • abnormal dopamine level(MP:0001905)

  • abnormal mating frequency(MP:0001377)

  • decreased litter size(MP:0001935)

  • impaired behavioral response to addictive substance(MP:0009750)
    • more 1 phenotypes
  • pup cannibalization(MP:0001385)
    • Detailed phenotype data

    Ordering Information

    Donor DNAherpes simplex virus thymidine kinase prpmoter (MC1 prpmoter), E. coli neo, polyA, mouse Apba1 genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Neurosci. Res., 43, 251-257 (2002). J. Biol. Chem. 283, 35763-35771 (2008). The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research.
    DepositorToshiharu Suzuki (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data