Strain Data Sheet

RBRC10447

Strain Information

Image
BRC No.RBRC10447
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129S6-Mapk8ip1<tm1Rjd>/Tsuz
Former Common nameJNK-interacting protein 1 (JIP1)-KO mice
H-2 Haplotype
ES Cell lineTC1 [129S6/SvEvTac]
Background strain
Appearance
Strain developmentDeposited by Toshiharu Suzuki, Hokkaido University in 2018. This mutated allele was originally generated by Dr. Rojer J Davis using ES cells derived from 129S6. This strain was further backcrossed to C57BL/6J for 5 to 6 generations by the depositor.
Strain descriptionMapk8ip1 (mitogen-activated protein kinase 8 interacting protein 1, JNK-interacting protein 1) knockout mice. Homozygous mutants are fertile.
Colony maintenance
References
Requirement of the JIP1 scaffold protein for stress-induced JNK activation.
Whitmarsh A J, Kuan C Y, Kennedy N J, Kelkar N, Haydar T F, Mordes J P, Appel M, Rossini A A, Jones S N, Flavell R A, Rakic P, Davis R J
Genes & Dev., 15(18), 2421-2432 (2001). 11562351

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Mapk8ip1mitogen-activated protein kinase 8 interacting protein 12Mapk8ip1targeted mutation 1, Roger J Davis
  • type 2 diabetes mellitus(MedGEN)
    • neoneomycin resistance gene (E. coli)2mouse phosphoglycerate kinase promoter (PGK promoter)
  • type 2 diabetes mellitus(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • abnormal NMDA-mediated synaptic currents(MP:0002888)

  • decreased susceptibility to neuronal excitotoxicity(MP:0008236)

  • homeostasis/metabolism phenotype(MP:0005376)
    • Detailed phenotype data

    Ordering Information

    Donor DNAmouse phosphoglycerate kinase promoter (PGK promoter), E.coli neo resistance gene, mouse Mapk8ip1 genomic DNA
    Research application
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Genes & Dev., 15(18), 2421-2432 (2001).In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the Original researcher Dr. Roger J. Davis is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit organization for a not-for-profit research. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from Dr. Roger J. Davis (Roger.Davis@umassmed.edu) using the Approval Form. For use of the BIOLOGICAL RESOURCE by a for-profit organization, the RECIPIENT must reach agreement on terms and conditions of use of it with Dr. Roger J. Davis and must obtain a prior written consent from the Dr. Roger J. Davis. RECIPIENT must contact Dr. Roger J. Davis in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorToshiharu Suzuki (Hokkaido University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data