Strain Data Sheet



BRC No.RBRC10321
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain name129.129P2-Aldh2<tm1Kaw>
Former Common nameAldh2 KO mice
H-2 Haplotype
ES Cell lineE14 [129P2/OlaHsd]
Background strain
Strain developmentDeveloped by Kyoko Kitagawa, University of Occupational and Environmental Health in 1998. E14 ES cells were used. The mutant mice were backcrossed to 129 over 7 times.
Strain descriptionAldh2 gene knockout mice. A termination codon and a neomycin selection cassette was inserted into exon 3 of Aldh2 gene.
Colony maintenance
ReferencesProc. Natl. Acad. Sci. USA, 102, 12159-12164 (2005). 16103363
FEBS Lett. 476, 306-311 (2000). 10913633
Alcohol Clin. Exp. Res. 29(11), 1959-1264 (2005). 16340452
Toxicol. Mech. Methods., 19(9), 535-540 (2009). 19874182

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Aldh2aldehyde dehydrogenase 2, mitochondrial5Aldh2<tm1Kaw>targeted mutation 1, Toshihiro Kawamoto

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
neoneomycin resistance gene (E. coli)5mouse phosphoglycerate kinase promoter (PGK promoter)

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
SV40 polyA5


Donor DNAE. coli Neomycin resistant gene, mouse Aldh2 genomic DNA, SV40 PolyA signal, Mouse Phosphoglycerate kinase promoter (PGK promoter)
Research application
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorKeiichi Nakayama (Kyushu University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.Necessary documents for ordering:
  1. Approval form (Japanese / English)
  2. Order form (Japanese / English)
  3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  4. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data