Strain Data Sheet
RBRC10321
Information1 | |
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| Image | |
| BRC No. | RBRC10321 |
| Type | Targeted Mutation |
| Species | Mus musculus |
| Strain name | 129.129P2-Aldh2<tm1Kaw> |
| Former Common name | Aldh2 KO mice |
| H-2 Haplotype | |
| ES Cell line | E14 [129P2/OlaHsd] |
| Background strain | |
| Appearance | |
| Strain development | Developed by Kyoko Kitagawa, University of Occupational and Environmental Health in 1998. E14 ES cells were used. The mutant mice were backcrossed to 129 over 7 times. |
| Strain description | Aldh2 gene knockout mice. A termination codon and a neomycin selection cassette was inserted into exon 3 of Aldh2 gene. |
| Colony maintenance | |
| References | Proc. Natl. Acad. Sci. USA, 102, 12159-12164 (2005). 16103363 FEBS Lett. 476, 306-311 (2000). 10913633 Alcohol Clin. Exp. Res. 29(11), 1959-1264 (2005). 16340452 Toxicol. Mech. Methods., 19(9), 535-540 (2009). 19874182 |
Health Report | |
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| Examination Date / Room / Rack | |
Gene | |
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| Gene info | Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter neoneomycin resistance gene (E. coli)5mouse phosphoglycerate kinase promoter (PGK promoter) Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter SV40 polyA5 |
Information2 | |
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| Donor DNA | E. coli Neomycin resistant gene, mouse Aldh2 genomic DNA, SV40 PolyA signal, Mouse Phosphoglycerate kinase promoter (PGK promoter) |
| Research application | |
| Specific Term and Conditions | Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. |
| Depositor | Keiichi Nakayama (Kyushu University) |
| Strain Status |  Frozen embryos |
| Strain Availability |  Recovery and QC required prior to distribution |
| Additional Info. | Necessary documents for ordering: |
BRC mice in Publications |
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