Strain Data Sheet

RBRC10306

Strain Information

Image
BRC No.RBRC10306
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC57BL/6-Foxc2<tm1.1Motoj>
Former Common namefloxed Foxc2
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Masaru Motojima, Tokai University in 2015. MK6 ES cells derived from C57BL/6J were used. C57BL/6J background.
Strain descriptionFoxc2(forkhead box C2) floxed mouse.
Colony maintenance
References
Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system.
Motojima M, Ogiwara S, Matsusaka T, Kim S Y, Sagawa N, Abe K, Ohtsuka M
Mamm. Genome, 27 (1-2), 62-69 (2016). 26542959

Health Report

Examination Date / Room / Rack2024/11/05Room:2-検Rack:C
2024/08/05Room:2-検Rack:C

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Foxc2
MGI:1347481
forkhead box C28Foxc2<tm1.1Motoj> targeted mutation 1.1, Masaru Motojima
  • lymphedema-distichiasis syndrome(DisGeNET, MedGEN)
  • Frt yeast FRT (flippase recombination target) site8Frt
    Frt yeast FRT (flippase recombination target) site8Frt
    loxP phage P1 loxP8loxP
    loxP phage P1 loxP8loxP
    loxP phage P1 loxP8loxP
    neo neomycin resistance gene (E. coli)8 mouse Phosphoglycerate kinase promoter (PGK promoter), phage T7 gb2 promoter
    rox Bacteriophage D6 rox site8rox

    Phenotype

    Annotation by Mammalian phenotyhpe ontology
    Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, Phage D6 Rox site, yeast FRT (flipase recombination target) sites, mouse Phosphoglycerate kinase promoter (PGK promoter), phage T7 gb2 promoter(synthetic), E. coli Neomycin resistance gene, mouse Foxc2 genomic DNA
    Research applicationCre/loxP system
    Developmental Biology Research
    FLP/frt system
    Hematological Research
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorMasaru Motojima (Tokai University)
    Strain Statusan icon for Live miceLive mice
    an icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data