Strain Data Sheet

RBRC10245

Strain Information

Image
BRC No.RBRC10245
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Tnfrsf13c<tm2.1Mass>
Former Common nameBAFF-R conditional knockout mouse
H-2 Haplotype
ES Cell lineBruce 4 [B6.Cg-Thy1<a>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
TNF family member B cell-activating factor (BAFF) receptor-dependent and -independent roles for BAFF in B cell physiology.
Sasaki Y, Casola S, Kutok J L, Rajewsky K, Schmidt-Supprian M
J. Immunol., 173, 2245-2252 (2004). 15294936

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site15Frt
Tnfrsf13c
MGI:1919299		tumor necrosis factor receptor superfamily, member 13c15Tnfrsf13c<tm2.1Mass>
MGI:4949656		targeted mutation 2.1, Marc Schmidt-Supprian
  • immunodeficiency, common variable, 2(MedGEN)

  • immunodeficiency, common variable, 4(MedGEN)
    • loxP phage P1 loxP15loxP
    loxP phage P1 loxP15loxP

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • absent marginal zone B cells (MP:0008183)

  • decreased B cell number (MP:0005017)

  • decreased IgG1 level (MP:0008495)

  • decreased IgG2a level (MP:0008496)

  • decreased IgG2b level (MP:0008497)
    • more 4 phenotypes
  • decreased IgG3 level (MP:0008498)

  • decreased transitional stage T2 B cell number (MP:0009926)

  • decreased transitional stage T3 B cell number (MP:0010228)

  • increased transitional stage T1 B cell number (MP:0009922)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP sites, yeast FRT (flippase recombination target) site, mouse Tnfrsf13c genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Immunology, 173, 2245-2252 (2004).
    DepositorYoshiteru Sasaki (Kyoto University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data