Strain Data Sheet



BRC No.RBRC10161
SpeciesMus musculus
Strain nameB6;B6D2-Tg(Myh6-Mas1)BChuan
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Strain developmentDeveloped by Takashi Iwamoto, Chubu University in 2015. B6D2F1 fertilized eggs were usedfor microinjection. Mice were backcrossed to C57BL/6J three times.
Strain descriptionTransgenic line expressing murine Mas1 oncogene under the control of the murine Myh6 (myosin, heavy polypeptide 6) promoter. Two sublines (A, RBRC10160; B, RBRC10161) are available. The renin–angiotensin system (RAS) plays a pivotal role in the pathogenesis of cardiovascular diseases. G protein-coupled receptor Mas1 is a receptor for angiotensin (Ang) –(1-7), and ACE2/ Ang-(1-7)/MAS1 receptor axis have been shown to antagonize ACE1/Ang-II/AT1 receptor axis. However, this idea recently looks to become skeptical, and the physiological role of MAS1 in the hearts remains to be determined. B6;B6D2-Tg(Myh6-Mas1)AChuan (RBRC10160) and B6;B6D2-Tg(Myh6-Mas1)BChuan (RBRC10161) overexpress mouse MAS1 gene in cardiomyocytes and die earlier due to heart failure. B6;B6D2-Tg(Myh6-Mas1)BChuan (RBRC10161) mice express MAS1 gene much more highly than B6;B6D2-Tg(Myh6-Mas1)AChuan (RBRC10160) mice, and careful breeding is necessary.
Colony maintenance
ReferencesHypertension, 47(5), 996-1002 (2006). 16567589
Am. J. Physiol. Heart Circ. Physiol., 302(1), H299-311 (2012). 22003054

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
GHGrowth hormone polyA (human)UNGH

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Mas1MAS1 oncogeneUNMas1mouse Myh6 promoter


Donor DNAbeta-myosin heavy chain genomic DNA, Mus musculus alpha-myosin heavy chain promoter, Mus musculus MAS1 receptor cDNA, Homo sapiens Growh hormone polyA signal
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 後日指定。In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURSE only for publication of research papers. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorTakashi Iwamoto (Chubu University)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
Cryopreserved embryos (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

BRC mice in Publications

No Data