Strain Data Sheet

RBRC10041

Strain Information

Image
BRC No.RBRC10041
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Mapt<tm1.1(MAPT)Tcs> App<tm1(NL)Tcs>
Former Common name
H-2 Haplotype
ES Cell lineiTL BA1[(C57BL/6N x 129S6/SvEvTac)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
ReferencesNat. Commun., 10(1):2394 (2019). 31160584
Nat. Neurosci., 17(5):661-663 (2014). 24728269
Front. Neurosci., 16:807473 (2022). 35431779
J. Biol. Chem., 294(34):12754-12765 (2019). 31273083

Health Report

Examination Date / Room / Rack2024/05/27Room:4-BRack:K
2024/02/26Room:4-BRack:K
2023/11/27Room:4-BRack:K

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Maptmicrotubule-associated protein tau11Mapt<tm1.1(MAPT)Tcs>targeted mutation 1.1, Takaomi C. Saido

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Frtyeast FRT (flippase recombination target) site11Frt

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
MAPTmicrotubule-associated protein tau (human)11MAPT

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP11loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Appamyloid beta (A4) precursor protein16App<tm1(NL)Tcs>targeted mutation 1, Takaomi C. Saido

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Frtyeast FRT (flippase recombination target) site16Frt

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP16loxP

Ordering Information

Donor DNAhuman MAPT genomic DNA, yeast FRT site, Phage P1 loxP site, mouse Mapt genomic DNA, phage P1 loxP site, yeast FRT (flipase recombination target) site, mouse App genomic DNA (mutant type)
Research applicationCre/loxP system
FLP/frt system
Mouse Models for Human Disease
Specific Term and ConditionsThe BIOLOGICAL RESOURCE is the property of the RIKEN (The Institute of Physical and Chemical Research). RECIPIENT agrees to acknowledge Shoko HASHIMOTO, Takashi SAITO and Takaomi C. SAIDO in an acknowledgement section. RECIPIENT also agrees to cite Nature Neuroscience 17, 661-663 (2014), Nature Communications 10: 2394 (2019) and Journal of Biological Chemistry, 294: 12754-12765 (2019) in all publications obtained using BIOLOGICAL RESOURCE. RECIPIENT agrees to acknowledge DEPOSITOR in all oral presentations and written publications as related to the BIOLOGICAL RESOURCE. RECIPIENT shall keep confidential any or all information marked CONFIDENTIAL that is received from DEPOSITOR and related to the BIOLOGICAL RESOURCE including oral discussions if they are reduced to writing within thirty (30) days and are marked "CONFIDENTIAL". For-profit organizations must contact the DEPOSITOR (takaomi.saido@riken.jp) for a licensing contract. If any invention is conceived and reduced to practice by RECIPIENT in the performance of the Research Plan involving the BIOLOGICAL RESOURCE during the term of this MTA, RECIPIENT agrees to promptly inform the invention to DEPOSITOR and the parties will consult each other to determine inventorship and ownership of the invention based on the respective parties contribution to the invention, before filing an application for a patent. In the case of a jointly owned application, the parties will separately enter into a joint application agreement including the sharing of ownership, patent costs and licensing income, as well as the responsible party for the application procedures etc.
DepositorTakaomi C. Saido (RIKEN CBS)
Strain Statusan icon for Live miceLive mice
an icon for Frozen embryosFrozen embryos
an icon for Frozen spermFrozen sperm
Strain AvailabilityCryopreserved sperm (within 1 month)
Cryopreserved embryos (within 1 month)
Live mouse (3 to 6 months)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)
Lab HP (Japanese/English)
Genotyping protocol -PCR-

BRC mice in Publications

Hiroki Sasaguri, Shoko Hashimoto, Naoto Watamura, Kaori Sato, Risa Takamura, Kenichi Nagata, Satoshi Tsubuki, Toshio Ohshima, Atsushi Yoshiki, Kenya Sato, Wakako Kumita, Erika Sasaki, Shinobu Kitazume, Per Nilsson, Bengt Winblad, Takashi Saito, Nobuhisa Iwata, Takaomi C. Saido
Recent Advances in the Modeling of Alzheimer’s Disease
Frontiers Neuroscience 16 (2022) 35431779