RBRC09804

Information1

Image
BRC No.RBRC09804
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameB6;B6D2-Tg(Myh6-HK2)AChuan
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain descriptionHexokinase 2, which phosphorylates glucose to form G6P, is a key enzyme in glucose metabolism. A growing body of evidence has shown that HK2 is involved in cardioprotection. These transgenic mice overexpress human HK2 in the heart muscle and have no obvious abnormality. It was reported that cardiac overexpression of mouse HK2 attenuated hypertrophy by increasing pentose phosphate pathway.
Colony maintenance
ReferencesJ. Am. Heart Assoc. 2013 Nov 4;2(6):e000355. 24190878

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
GHGrowth hormone polyA (human)UNGH

Gene symbolGene nameChr.Allele symbolAllele namePromoter
HK2Hexokinase 2 (human)UNHK2Rat Myh6 promoter

Information2

Donor DNAHomo sapiens Growth hormone polyA signal, Mouse alpha-myosin heavy chain promoter, Homo sapiens Hexokinase 2
Research applicationCardiovascular Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. 後日指定。In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURSE only for publication of research papers. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorTakashi Iwamoto (Chubu University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.

BRC mice in Publications

No Data