BRC No.RBRC09735
SpeciesMus musculus
Strain nameC57BL/6N-Tg(CAG-EGFP,-IL6/mCherry)56Kenw
Former Common nameLGL-IL6 (Li56)
H-2 Haplotype
ES Cell line
Background strainC57BL/6NCrSlc
Strain developmentDeveloped by Ken Watanabe, National Center for Geriatrics and Gerontology in 2015. C57BL/6N genetic background.
Strain descriptionTransgenic mouse line to express Human IL-6 in a Cre-dependent manner. CAG promoter drives loxP-GFP-pA-loxP-IL-6-2A-mCherry-pA. Another transgenic subline of RBRC09735 is available as RBRC09734.
Colony maintenance
ReferencesMori et al. Exp. Anim. (2016) 27349442

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter


Donor DNACMV Early enhancer, Chiken Beta actin promoter, Rabbit Beta globin splice acceptor site, Bacteriophage loxP element, Aequorea victoria EGFP, SV40 PolyA signal, Human IL-6, Mouse Proacrosin signal sequence; Thy-1 GPI anchor signal sequence, Thosea asigna virus 2A peptide, Discosoma sp. mCherry, Bovine GH polyA signal
Research applicationCre/loxP system
Fluorescent Proteins/lacZ System
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Mori et al. Exp. Anim. (2016)
DepositorKen Watanabe (National Center for Geriatrics and Gerontology)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-
Category I MTA: FP license of TBUSA
GFP Transfer License (Japanese / English)
Please fill in the Schedule A, and submit two signed copies to us together with two signed copies of RIKEN BRC's MTA. Please also read Schedule B.

BRC mice in Publications

No Data