BRC No.RBRC09702
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.129-Mta1<tm1Nkcc>
Former Common nameMta1 KO
H-2 Haplotype
ES Cell lineE14TG2a [129P2/OlaHsd]
Background strain
Strain developmentDeveloped by Soichi Takiguchi, National Hospital Organization Kyushu Cancer Center, in collaboration with Graduate School of Pharmaceutical Sciences, The University of Tokyo in 2002. E14TG2aIV ES cell line (129P2/OlaHsd) was used. C57BL/6J congenic strain (backcrossed to C57BL/6J for 35 generations).
Strain descriptionMta1 (metastasis associated 1) knockout mice. A genomic fragment corresponding from exon 10 to exon 13 of the Mta1 gene was replaced with a Neo resistance gene. The rate of homozygous mutants born from hetero x hetero crossing is much lower than what is expected from the Mendel’s law of inheritance.
Colony maintenance

Health Report

Examination Date / Room / RackNo Data


Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Mta1metastasis associated 112Mta1<tm1Nkcc>targeted mutation 1, Soichi Takiguchi

Gene symbolGene nameChr.Allele symbolAllele namePromoter
neoneomycin resistance gene (E. coli)12mouse RNA polymerase II promoter (PolII promoter)


Donor DNAmouse Polr2a promoter, E. coli neo, human hypoxanthine phosphoribosyl transferase 1 polyA signal, mouse Mta1 genomic DNA
Research applicationCancer Research
Specific Term and ConditionsThe RECIPIENT of BIOLOGICAL RESOURCE must obtain a prior written consent on use of it from the DEPOSITOR/DEVELOPER. The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use or publication with the results from the use of the BIOLOGICAL RESOURCE. The RECIPIENT agrees to use this BIOLOGICAL RESOURCE as a collaboration with the DEPOSITOR. However, it may not be a collaboration if the research interest is out of field of the DEPOSITOR.
DepositorSoichi Takiguchi (National Hospital Organization Kyushu Cancer Center)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data