Strain Data Sheet

RBRC09686

Strain Information

Image
BRC No.RBRC09686
TypeChemically-induced Mutation Congenic
SpeciesMus musculus
Strain nameC3.B6-Tdrd12<repro23>
Former Common nameRepro23
H-2 Haplotype
ES Cell line
Background strainC3H/HeJJcl
Appearance
Strain developmentDeveloped by the NIH-supported Reproductive Genomics program at JAX. Deposited by Tetsuo Kunieda, Okayama University in 2016. C3H congenic line.
Strain descriptionAn ENU-induced mutant line harboring a nonsense mutation of the 8th exon of the mouse Tdrd12 (Tudor domain containing 12) gene. Male homozygotes exhibit infertility. Female homozygotes are fertile.
Colony maintenance
References
Characterization and linkage mapping of an ENU-induced mutant mouse with defective spermatogenesis.
Asano Y, Akiyama K, Tsuji T, Takahashi S, Noguchi J, Kunieda T
Exp. Anim., 58. 525-532, (2009). 19897936

Tudor domain containing 12 (TDRD12) is essential for secondary PIWI interacting RNA biogenesis in mice.
Pandey R R, Tokuzawa Y, Yang Z, Hayashi E, Ichisaka T, Kajita S, Asano Y, Kunieda T, Sachidanandam R, Chuma S, Yamanaka S, Pillai R S
Proc. Natl. Acad. Sci. USA, 110, 16492-16497 (2013). 24067652

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Tdrd12
MGI:1919231		tudor domain containing 127Tdrd12<repro23>
MGI:3512943		reproductive mutant 23, JAX Reproductive Mutagenesis Program

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal male germ cell morphology (MP:0006362)

  • abnormal sperm physiology (MP:0004543)

  • abnormal spermatid morphology (MP:0006380)

  • absent germ cells (MP:0004806)

  • absent ovarian follicles (MP:0002777)
    • more 19 phenotypes
  • arrest of male meiosis (MP:0008261)

  • arrest of spermatogenesis (MP:0001155)

  • azoospermia (MP:0005159)

  • cellular phenotype (MP:0005384)

  • decreased cell proliferation (MP:0000352)

  • decreased enterocyte cell number (MP:0000339)

  • decreased epididymis weight (MP:0004929)

  • decreased male germ cell number (MP:0004901)

  • decreased oocyte number (MP:0005431)

  • decreased primordial germ cell number (MP:0008392)

  • decreased testis weight (MP:0004852)

  • embryonic lethality, incomplete penetrance (MP:0011102)

  • female infertility (MP:0001926)

  • increased enterocyte apoptosis (MP:0008885)

  • male infertility (MP:0001925)

  • prenatal growth retardation (MP:0010865)

  • reproductive system phenotype (MP:0005389)

  • small ovary (MP:0001127)

  • small testis (MP:0001147)
    • Detailed phenotype data

    Ordering Information

    Donor DNA
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
    DepositorTetsuo Kunieda (Okayama University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovery and QC required prior to distribution
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)

    BRC mice in Publications

    No Data