RBRC09685

Information1

Image
BRC No.RBRC09685
TypeChemically-induced Mutation Congenic
SpeciesMus musculus
Strain nameC3B6-Mad2l2<repro22>
Former Common namerepro22
H-2 Haplotype
ES Cell line
Background strainC3H/HeJJcl
Appearance
Strain developmentDeveloped by the NIH-supported Reproductive Genomics program at JAX. Deposited by Tetsuo Kunieda, Okayama University in 2016. C57BL/6 and C3H mixed genetic backgrounds.
Strain descriptionAn ENU-induced mutant line harboring a missense mutation in the 3rd exon of the mouse Mad2l2 (MAD2 mitotic arrest deficient-like 2) gene. Amino acid substitution of arginine for cysteine at position 70 (C70R). Both male and female homozygotes exhibit infertility. Female homozygotes develop ovarian tumors at a high frequency.
Colony maintenance
ReferencesJ. Reprod. Dev. 54, 225-228, (2008). 18385543
Mol. Cell Endocrinol., 412, 19-25, (2015). 26004212
J. Biol. Chem., 289, 3811-3824, (2014). 24356953

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Mad2l2MAD2 mitotic arrest deficient-like 24Mad2l2<repro22>reproductive mutant 22, JAX Reproductive Mutagenesis Program

Information2

Donor DNA
Research application
Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form.
DepositorTetsuo Kunieda (Okayama University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data