RBRC09677

Information1

Image
BRC No.RBRC09677
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL/6-Tg(Camk2a-Crem)I23Nkoji
Former Common nameICER-I-OE
H-2 Haplotype
ES Cell line
Background strainC57BL/6JJcl
Appearance
Strain developmentDeveloped by Shogo Endo and Nobuhiko Kojima, Tokyo Metropolitan Institute of Gerontology. The Camk2a promoter was used to drive brain expression of splice variant I of Crem.A DNA construct was injected to fertilized eggs in B6/C3H/F1 background (RBRC09675) or C57BL6/J background (RBRC09676, RBRC09677). Mice were backcrossed to C57BL/6J.
Strain descriptionICER(Inducible cAMP early repressor)-I overexpressing mice under the control of CaMKIIα promoter. No overt change in brain anatomy and general behavior. Impairment in consolidation of fear memory. Attenuation of amygdala kindling.
Colony maintenance
ReferencesJ. Neurosci., 28, 6459-6472 (2008). 18562617

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
CremcAMP responsive element modulatorUNCremmouse Camk2a promoter

Information2

Donor DNAM Musculus ICER-I cDNA, SV40 polyA signal, M Musculus CaMKIIα promoter, adenovirus tripartite leader sequence +14〜+200, Mus musculus IgG variable region(3'-splice sequence)
Research applicationNeurobiology Research
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. J. Neurosci., 28, 6459-6472 (2008).The RECIPIENT must close MTA with Tokyo Metropolitan Institute of Gerontology.
DepositorShogo Endo (Tokyo Metropolitan Institute of Gerontology)
Strain Statusan icon for Frozen embryosFrozen embryos
Strain AvailabilityRecovery and QC required prior to distribution
Additional Info.

BRC mice in Publications

No Data