Strain Data Sheet



BRC No.RBRC09647
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6;Cg-Notch2<tm1.1Hhi>
Former Common nameNotch2 flox
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strainC57BL/6JJcl
Strain developmentDeveloped by Shigeru Chiba, University of Tsukuba. TT2 ES [(C57BL/6NCrlj x CBA/JNCrlj)F1] was used. C57BL/6N and CBA mixed background.
Strain descriptionFolxed Notch2 mice. A pair of loxP sites are flanking exons encoding transmembrane domain of the Notch2 gene.
Colony maintenance
ReferencesImmunity, 18, 675-685 (2003). 12753744

Health Report

Examination Date / Room / Rack


Gene info
Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
Notch2Notch gene homolog 2 (Drosophila)3Notch2<tm1.1Hhi>targeted mutation 1.1, Hisamaru Hirai

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP3loxP

Gene symbolGene nameChr.Allele symbolAllele nameCommon namesPromoter
loxPphage P1 loxP3loxP


Donor DNAphage P1 loxP sites, mouse Notch2 genomic DNA
Research applicationCre/loxP system
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity, 18, 675-685 (2003). For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR.
DepositorShigeru Chiba (University of Tsukuba)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Necessary documents for ordering:
  1. Order form (Japanese / English)
  2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
  3. Acceptance of responsibility for living modified organism (Japanese / English)

Genotyping protocol -PCR-

BRC mice in Publications

No Data