Strain Information | |
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Image | |
BRC No. | RBRC09647 |
Type | Targeted Mutation |
Species | Mus musculus |
Strain name | B6;Cg-Notch2<tm1.1Hhi> |
Former Common name | Notch2 flox |
H-2 Haplotype | |
ES Cell line | TT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1] |
Background strain | C57BL/6JJcl |
Appearance | |
Strain development | Developed by Shigeru Chiba, University of Tsukuba. TT2 ES [(C57BL/6NCrlj x CBA/JNCrlj)F1] was used. C57BL/6N and CBA mixed background. |
Strain description | Folxed Notch2 mice. A pair of loxP sites are flanking exons encoding transmembrane domain of the Notch2 gene. |
Colony maintenance | |
References | Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Saito T, Chiba S, Ichikawa M, Kunisato A, Asai T, Shimizu K, Yamaguchi T, Yamamoto G, Seo S, Kumano K, Nakagami-Yamaguchi E, Hamada Y, Aizawa S, Hirai H Immunity, 18, 675-685 (2003). 12753744 |
Health Report | |
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Examination Date / Room / Rack |
Gene | |||||||
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Gene Symbol | Gene Name | Chr. | Allele Symbol | Allele Name | Common Names | Promoter | Diseases Related to This Gene |
Notch2 | notch 2 | 3 | Notch2 | targeted mutation 1.1, Hisamaru Hirai | |||
loxP | phage P1 loxP | 3 | loxP | ||||
loxP | phage P1 loxP | 3 | loxP |
Phenotype | |
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Annotation by Mammalian phenotyhpe ontology | |
Detailed phenotype data |
Ordering Information | |
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Donor DNA | phage P1 loxP sites, mouse Notch2 genomic DNA |
Research application | Cre/loxP system |
Specific Term and Conditions | In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Immunity, 18, 675-685 (2003). For use of the BIOLOGICAL RESOURCE by a for-profit institution, the RECIPIENT must reach agreement on terms and conditions of use of it with DEPOSITOR and must obtain a prior written consent from the DEPOSITOR. |
Depositor | Shigeru Chiba (University of Tsukuba) |
Strain Status | Frozen sperm |
Strain Availability | Recovered litters from cryopreserved sperm (2 to 4 months) Cryopreserved sperm (within 1 month) |
Additional Info. | Necessary documents for ordering:
Genotyping protocol -PCR- |
BRC mice in Publications |
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No Data |