Strain Data Sheet

RBRC09642

Strain Information

Image
BRC No.RBRC09642
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameTg(SOD1*H46R)IAra
Former Common nameSOD1(H46R)Tg
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
A cysteine residue affects the conformational state and neuronal toxicity of mutant SOD1 in mice: relevance to the pathogenesis of ALS.
Nagano S, Takahashi Y, Yamamoto K, Masutani H, Fujiwara N, Urushitani M, Araki T
Human Molecular Genetics., 24, 3427-3439 (2015). 25762155

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
SOD1superoxide dismutase 1, soluble (human)UNSOD1

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • impaired coordination(MP:0001405)

  • paralysis(MP:0000753)

  • premature death(MP:0002083)

  • weight loss(MP:0001263)
    • Detailed phenotype data

    Ordering Information

    Donor DNAhuman Cu/Zn SOD1 gene(H46R)
    Research application
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. The research by use of the BIOLOGICAL RESOURCE shall be regarded as collaboration by the RECIPIENT and the DEPOSITOR.
    DepositorToshiyuki Araki (National Center of Neurology and Psychiatry)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data