Strain Data Sheet

RBRC09620

Strain Information

Image
BRC No.RBRC09620
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Runx2<tm1.1Taks>
Former Common nameRunx2-flox
H-2 Haplotype
ES Cell lineBruce 4 [B6.Cg-Thy1<a>]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development.
Kosei Nagata, Hironori Hojo, Song Ho Chang, Hiroyuki Okada, Fumiko Yano, Ryota Chijimatsu, Yasunori Omata, Daisuke Mori, Yuma Makii, Manabu Kawata, Taizo Kaneko, Yasuhide Iwanaga, Hideki Nakamoto, Yuji Maenohara, Naohiro Tachibana, Hisatoshi Ishikura, Junya Higuchi, Yuki Taniguchi, Shinsuke Ohba, Ung-Il Chung, Sakae Tanaka, Taku Saito
Nat. Commun., 13(1):6187 (2022). doi: 10.1038/s41467-022-33744-5. 36261443

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frtyeast FRT (flippase recombination target) site17Frt
  • cleidocranial dysplasia 1(DisGeNET, MedGEN)

  • metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome(MedGEN)
    • Runx2runt related transcription factor 217Runx2targeted mutation 1.1, Taku Saito
  • cleidocranial dysplasia 1(DisGeNET, MedGEN)

  • metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome(MedGEN)
    • loxPphage P1 loxP17loxP
  • cleidocranial dysplasia 1(DisGeNET, MedGEN)

  • metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome(MedGEN)
    • loxPphage P1 loxP17loxP
  • cleidocranial dysplasia 1(DisGeNET, MedGEN)

  • metaphyseal dysplasia-maxillary hypoplasia-brachydacty syndrome(MedGEN)

    • Phenotype

    Annotation by Mammalian phenotyhpe ontology
  • no abnormal phenotype detected(MP:0002169)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, yeast Frt (flippase recombination target) site, mouse Runx2 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Nat Commun., 13(1):6187 (2022). doi: 10.1038/s41467-022-33744-5.In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested.
    DepositorTaku Saito (The University of Tokyo)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data