Strain Data Sheet

RBRC09599

Strain Information

Image
BRC No.RBRC09599
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameFVB.129S6-Cd109<tm1Mat>
Former Common nameCD109-KO
H-2 Haplotype
ES Cell lineCSL3[129S6/SvEvTac]
Background strainFVB/NJcl
Appearance
Strain development
Strain description
Colony maintenance
References
Epidermal hyperplasia and appendage abnormalities in mice lacking CD109.
Mii S, Murakumo Y, Asai N, Jijiwa M, Hagiwara S, Kato T, Asai M, Enomoto A, Ushida K, Sobue S, Ichihara M, Takahashi M
Am. J. Pathol, 181(4), 1180-1189 (2012). 22846721

Suppression of skin tumorigenesis in CD109-deficient mice.
Sunagawa M, Mii S, Enomoto A, Kato T, Murakumo Y, Shiraki Y, Asai N, Asai M, Nagino M, Takahashi M
Oncotarget, 2016 Oct 14. doi: 10.18632/oncotarget.12653. 27756876

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Cd109
MGI:2445221
CD109 antigen9Cd109<tm1Mat>
MGI:5443927
targeted mutation 1, Masahide Takahashi
HBB human beta-globin polyA9HBB
lacZ beta-galactosidase (E. coli)9
neo neomycin resistance gene (E. coli)9 mouse phosphoglycerate kinase promoter (PGK promoter)
nls SV40 large T antigen nuclear localization signal (NLS)9nls

Phenotype

Annotation by Mammalian phenotyhpe ontology
  • abnormal bone remodeling(MP:0002998)

  • abnormal epidermal layer morphology(MP:0001216)

  • abnormal femur morphology(MP:0000559)

  • abnormal hair follicle infundibulum morphology(MP:0010682)

  • abnormal hair growth(MP:0002073)
  • more 16 phenotypes
  • abnormal hair shaft morphology(MP:0003809)

  • abnormal skin adnexa morphology(MP:0010678)

  • decreased bone trabecula number(MP:0010869)

  • decreased bone volume(MP:0010876)

  • decreased compact bone thickness(MP:0000135)

  • dilated hair follicle(MP:0010699)

  • epidermal hyperplasia(MP:0001222)

  • focal hair loss(MP:0000418)

  • increased bone trabecular spacing(MP:0013630)

  • osteoporosis(MP:0000066)

  • sebaceous gland hyperplasia(MP:0009794)

  • skin inflammation(MP:0004947)

  • sparse hair(MP:0000416)

  • thick epidermis stratum basale(MP:0009715)

  • thick epidermis suprabasal layer(MP:0009612)

  • thick epidermis(MP:0001219)
  • Detailed phenotype data

    Ordering Information

    Donor DNAnuclear localization signal, E. coli lacZ gene, Mouse phosphoglycerate kinase (PGK) promoter, E. coli neomycin resistance gene, Human beta-globin polyA, Mouse Cd109 genomic DNA
    Research applicationFluorescent Proteins/lacZ System
    Specific Term and ConditionsPrior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must obtain approval from the DEPOSITOR using the Approval Form. In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Oncotarget, 2016 Oct 14. doi: 10.18632/oncotarget.12653.The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
    DepositorMasahide Takahashi (Nagoya University)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Approval form (Japanese / English)
    2. Order form (Japanese / English)
    3. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    4. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data