RBRC09559

Information1

Image
BRC No.RBRC09559
TypeTransgeneCartagena
SpeciesMus musculus
Strain nameC57BL-Tg(villin-Lin28A)B
Former Common name
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain descriptionLin28 is an RNA-binding protein that modulate the processing of let-7 microRNA. It is one of key elements for producing iPS cells and important in keeping pluripotent state of stem cells. Its involvement in cancer development has been also reported. Mice of these lines overexpress mouse Lin28A in the intestinal epithelium, resulting in tumor formation.
Colony maintenance
ReferencesGenes Dev., 15, 1074-1086 (2015). 25956904

Health Report

Examination Date / Room / RackNo Data

Gene

Gene info
Gene symbolGene nameChr.Allele symbolAllele namePromoter
Lin28Alin-28 homolog AUNLin28Amouse villin promoter

Gene symbolGene nameChr.Allele symbolAllele namePromoter
SV40 PolyA signalUN

Information2

Donor DNAmouse villin promoter, mouse Lin28A cDNA, SV40 PolyA signal
Research application
Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. (後日指定)In publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The RECIPIENT agrees to use the BIOLOGICAL RESOURSE only for publication of research papers.The RECIPIENT must contact the DEPOSITOR in the case of application for any patents or commercial use based on the results from the use of the BIOLOGICAL RESOURCE.
DepositorTakashi Iwamoto (Chubu University)
Strain Statusan icon for Frozen spermFrozen sperm
Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
Cryopreserved sperm (within 1 month)
Additional Info.Genotyping protocol -PCR-

BRC mice in Publications

No Data