Strain Data Sheet

RBRC09367

Strain Information

Image
BRC No.RBRC09367
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameC3;B6-Mef2d<tm1.2Tfur>
Former Common nameMef2d KO
H-2 Haplotype
ES Cell lineTC1 [129S6/SvEvTac]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Mef2d is essential for the maturation and integrity of retinal photoreceptor and bipolar cells.
Omori Y, Kitamura T, Yoshida S, Kuwahara R, Chaya T, Irie S, Furukawa T
Genes Cells, 20, 408-426 (2015). 25757744

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Frt yeast FRT (flippase recombination target) site3Frt
Mef2d
MGI:99533		myocyte enhancer factor 2D3Mef2d<tm1.2Tfur> targeted mutation 1.2, Takahisa Furukawa
loxP phage P1 loxP3loxP

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal electroretinogram waveform feature (MP:0012029)

  • abnormal retina bipolar cell morphology (MP:0006073)

  • abnormal retina cone bipolar cell morphology (MP:0006075)

  • abnormal retina cone cell outer segment morphology (MP:0008449)

  • abnormal retina horizontal cell morphology (MP:0006068)
    • more 12 phenotypes
  • abnormal retina outer nuclear layer morphology (MP:0003731)

  • abnormal retina outer plexiform layer morphology (MP:0003732)

  • abnormal retina rod cell outer segment morphology (MP:0008456)

  • decreased a-wave amplitude (MP:0012143)

  • decreased b-wave amplitude (MP:0012144)

  • decreased retina cone cell number (MP:0008446)

  • decreased retina rod cell number (MP:0008453)

  • retina outer nuclear layer degeneration (MP:0008518)

  • retina photoreceptor degeneration (MP:0008450)

  • short photoreceptor outer segment (MP:0008587)

  • thin retina outer nuclear layer (MP:0008515)

  • vision/eye phenotype (MP:0005391)
    • Detailed phenotype data

    Ordering Information

    Donor DNAphage P1 loxP site, yeast FRT (flipase recombination target) site, mouse Mef2d genomic DNA
    Research applicationCre/loxP system
    Developmental Biology Research
    FLP/frt system
    Neurobiology Research
    Sensorineural Research
    Specific Term and ConditionsIn publishing the research results to be obtained by use of the BIOLOGICAL RESOURCE, an acknowledgment to the DEPOSITOR is requested. The availability of the BIOLOGICAL RESOURCE is limited to a RECIPIENT of a not-for profit institution for a not-for-profit research. Prior to requesting the BIOLOGICAL RESOURCE, the RECIPIENT must contract an MTA with the DEPOSITOR (Osaka University).
    DepositorTakahisa Furukawa (Osaka University)
    Strain Statusan icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data