Strain Data Sheet

RBRC09341

Strain Information

Image
BRC No.RBRC09341
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameB6.Cg-Il33<tm1Snak>
Former Common nameIL-33(Acc.No.CDB0631K)
H-2 Haplotype
ES Cell lineTT2 [(C57BL/6NCrlj x CBA/JNCrlj)F1]
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
IL-33 is a crucial amplifier of innate rather than acquired immunity.
Keisuke Oboki, Tatsukuni Ohno, Naoki Kajiwara, Ken Arae, Hideaki Morita, Akina Ishii, Aya Nambu, Takaya Abe, Hiroshi Kiyonari, Kenji Matsumoto, Katsuko Sudo, Ko Okumura, Hirohisa Saito, Susumu Nakae
Proc. Natl. Acad. Sci. USA, 107(43):18581-6 (2010). 20937871

Health Report

Examination Date / Room / Rack

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
GFP Green Fluorescent Protein (Aequorea victoria)19
Il33
MGI:1924375		interleukin 3319Il33<tm1Snak>
MGI:4838250		targeted mutation 1, Susumu Nakae
loxP phage P1 loxP19loxP
loxP phage P1 loxP19loxP
neo neomycin resistance gene (E. coli)19 mouse phosphoglycerate kinase promoter (PGK promoter)

Phenotype

Phenotype annotation from literatures by Mammalian phenotype ontology
  • decreased airway responsiveness (MP:0002335)

  • decreased inflammatory response (MP:0001876)

  • decreased interleukin-1 alpha secretion (MP:0008655)

  • decreased interleukin-1 beta secretion (MP:0008658)

  • decreased interleukin-6 secretion (MP:0008706)
    • more 4 phenotypes
  • decreased susceptibility to endotoxin shock (MP:0008734)

  • decreased susceptibility to xenobiotic induced morbidity/mortality (MP:0009767)

  • increased susceptibility to induced colitis (MP:0008537)

  • lung inflammation (MP:0001861)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, mouse phosphoglycerate kinase promoter (PGK promoter), E. coli neomycin resistance gene, jellyfish GFP cDNA, mouse Il33 genomic DNA
    Research applicationCre/loxP system
    Fluorescent Proteins/lacZ System
    Immunology and Inflammation Research
    Specific Term and ConditionsIn publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the following literature(s) designated by the DEPOSITOR is requested. Proc. Natl. Acad. Sci. USA, 107(43):18581-6 (2010). In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0631K and Web Site (https://large.riken.jp/distribution/mutant-list.html) is requested. Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved sperm (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data