Strain Data Sheet

RBRC09330

Strain Information

Image
BRC No.RBRC09330
TypeTargeted MutationCartagena
SpeciesMus musculus
Strain nameAngpt1(Acc.No.CDB0627K)
Former Common nameAngpt1(Acc.No.CDB0627K), Ang1<fl>, Ang1<flox>
H-2 Haplotype
ES Cell line
Background strain
Appearance
Strain development
Strain description
Colony maintenance
References
Angiopoietin-1 guides directional angiogenesis through integrin alphavbeta5 signaling for recovery of ischemic retinopathy.
Lee J, Kim K E, Choi D K, Jang J Y, Jung J J, Kiyonari H, Shioi G, Chang W, Suda T, Mochizuki N, Nakaoka Y, Komuro I, Yoo O J, Koh G Y
Sci. Transl. Med., 5(203):203ra127 (2013). 24048525

Health Report

Examination Date / Room / Rack2025/07/28Room:4-ARack:KSentinel mouse program
2025/05/19Room:4-ARack:KSentinel mouse program
2025/02/17Room:4-ARack:KSentinel mouse program
2024/11/18Room:4-ARack:KSentinel mouse program
2024/08/19Room:4-ARack:KSentinel mouse program
2024/05/20Room:4-ARack:KSentinel mouse program
2024/02/19Room:4-ARack:KSentinel mouse program

Gene

Gene SymbolGene NameChr.Allele SymbolAllele NameCommon NamesPromoterDiseases Related to This Gene
Angpt1
MGI:108448		angiopoietin 115Angpt1<tm1.1Yona>
MGI:5585457		targeted mutation 1.1, Yoshikazu Nakaoka
  • angioedema, hereditary, 5(MedGEN)
    • Frt yeast FRT (flippase recombination target) site15Frt
    loxP phage P1 loxP15loxP
    loxP phage P1 loxP15loxP

    Phenotype

    Phenotype annotation from literatures by Mammalian phenotype ontology
  • abnormal choriocapillaris morphology (MP:0006238)

  • abnormal circulating insulin level (MP:0001560)

  • abnormal cone electrophysiology (MP:0004022)

  • abnormal retina cone cell morphology (MP:0001006)

  • decreased circulating insulin level (MP:0002727)
    • more 3 phenotypes
  • embryonic lethality (MP:0008762)

  • impaired glucose tolerance (MP:0005293)

  • normal phenotype (MP:0002873)
    • Detailed phenotype data

    Ordering Information

    Donor DNAPhage P1 loxP sites, yeast frt site, mouse Angpt1 genomic DNA
    Research applicationCre/loxP system
    FLP/frt system
    Specific Term and Conditions(1) The RECIPIENT shall obtain a prior agreement from the DEVELOPER Dr. Yoshikazu Nakaoka (National Cerebral and Cardiovascular Center )(ynakaoka@ncvc.go.jp) to transfer the BIOLOGICAL RESOURCE. (2) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the Acc.No. CDB0627K and Web Site (https://large.riken.jp/distribution/mutant-list.html) is requested. (3) In publishing the research results obtained by use of the BIOLOGICAL RESOURCE, a citation of the literature designed by the DEPOSITOR is requested (Sci Transl Med. 2013 5(203):203ra127.). (4) Please inform the DEPOSITOR (mutant.bdr@riken.jp) about the paper when published.
    DepositorRIKEN CDB (RIKEN CDB)
    Strain Statusan icon for Frozen embryosFrozen embryos
    an icon for Frozen spermFrozen sperm
    Strain AvailabilityRecovered litters from cryopreserved embryos (2 to 4 months)
    Cryopreserved sperm (within 1 month)
    Cryopreserved embryos (within 1 month)
    Additional Info.Necessary documents for ordering:
    1. Order form (Japanese / English)
    2. Category I MTA: MTA for distribution with RIKEN BRC (Japanese / English)
    3. Acceptance of responsibility for living modified organism (Japanese / English)

    Genotyping protocol -PCR-

    BRC mice in Publications

    No Data